Table 2 A comparison of acute myocardial infarction (AMI) and sepsis

Market issues

Significant publicity surrounding and general awareness of the condition; large trials

Lack of understanding among physicians and the general public

Diagnosis

A relatively straightforward and relatively common diagnosis (electrocardiogram, enzymes, troponin), and one that can be made by generalists, not just cardiology specialists

Complicated by a long list of signs and symptoms and few objective tools for validation

Comorbidities

Generally single organ disease (notable exception when complicated by cardiogenic shock)

Often chronic or acute comorbidities

Physician education

Generalists have been taught to recognize the signs and symptoms of AMI; initial treatment is usually provided by emergency physicians, who are trained to treat these patients

Sepsis patients often come 'second hand' from a specialist who may not be appropriately trained to diagnose, manage, and refer patients with sepsis