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Table 3 Neutrophil chemoattractant receptors and their ligands

From: Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance

Class

Receptors

Ligands

C-X-C receptors

CXCR1 (IL-8 receptor A)

IL-8

 

CXCR2 (IL-8 receptor B)

IL-8, GRO, NAP-2, ENA-78, GCP-2

 

CXCR3

Mig, IP-10

 

CXCR4

SDF-1

C-C receptors

CCR1

MIP-1α, MIP-1β, MCP-3

 

CCR2A, CCR2B

MCP-1, MCP-3

 

CCR3

Eotaxin, RANTES, MCP-3

 

CCR4

MIP-1α, RANTES, MCP-1

 

CCR5

MIP-1α, MIP-1β, RANTES

 

CCR6

MIP-3α

 

CCR7

ELC

 

CCR8

I-309

Non-C-X-C

C5aR

C5a

 

FMLPr

FMLP

  1. ELC, Epstein-Barr virus-induced molecule 1 ligand chemokine (CCL19); ENA, epithelial cell derived neutrophil activating peptide; FMLP, f-Met-Leu-Phe; GCP, granulocyte chemotactic protein; GRO, growth-related oncogene; IP, inducible protein; IP-10, interferon-gamma inducible protein; MCP, monocyte chemoattractant protein; Mig, monokine induced by interferon-gamma (CXCL9); MIP, macrophage inflammatory protein; NAP, neutrophil-activating peptide; RANTES, regulated upon activation, normal T cell expressed and secreted; SDF, stromal derived factor.
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