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Figure 3 | Critical Care

Figure 3

From: Science review: Mechanisms of ventilator-induced injury

Figure 3

Plasma IL-1β following 4 hours of mechanical ventilation in a rat model of acid aspiration. Ventilation with a tidal volume of 12 ml/kg significantly increased plasma levels of IL-1β compared with rats ventilated with 3 ml/kg and a similar level of positive end expiratory pressure (PEEP; cmH2O) (*P < 0.05 by paired t test, mean ± standard deviation). IL-1β levels in the 3 ml/kg acid-injured group were not different from those in uninjured rats ventilated with 12 ml/kg or from uninjured, never ventilated rats (n = 5 in each acid injured group and n = 3 in the uninjured groups).

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