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Figure 2 | Critical Care

Figure 2

From: Science review: Role of coagulation protease cascades in sepsis

Figure 2

Coreceptor-dependent activation of protease-activated receptors (PARs) by coagulation proteases. Relevant signaling complexes are schematically represented and the target PARs are listed. In primary endothelial cells, activated protein C (APC) signaling is mediated through PAR1, whereas tissue factor (TF)-VIIa-Xa can signal when PAR1 is blocked, indicating signaling through PAR2. TF–VIIa inefficiently signals in endothelial cells [20,22].

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Critical Care

ISSN: 1364-8535