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Table 3 Procalcitonin levels, SOFA and APACHE II scores

From: The effects of IgM-enriched immunoglobulin preparations in patients with severe sepsis [ISRCTN28863830]

Measurement

Day 1

Day 2

Day 3

Day 4

Day 5

Day 6

Day 7

Day 8

ANOVA

PCT (ng/mL)

         

   Pentaglobin®

5.5 (0.9–72.0)

3.5* (0.9–65.0)

3.5** (0.9–39.0)

3.05* (0.9–23.0)

2.6* (0.8–11.0)

2.45 (0.6–11.0)

2.0* (0.6–11.0)

1.45** (0.6–14.3)

<0.001

   Control

4.0 (0.4–194.0)

3.14 (0.4–72.0)

3.2 (0.2–34.0)

2.65 (0.6–18.0)

3.15 (0.5–14.0)

4.0 (0.6–21.6)

4.0 (0.3–117.0)

4.0 (0.5–185.0)

0.8

SOFA

         

   Pentaglobin®

5.0 (1.0–10.0)

6.0 (1.0–11.0)

6.0 (0–12)

5.0 (0–16)

4.0 (0.0–16.0)

4.0 (0–16)

3.5 (0.0–15.0)

4.0 (0–14)

0.2

   Control

4.5 (1.0–12.0)

5.5 (1.0–15.0)

5.0 (2–15)

5.0 (2–12)

4.5 (1.0–10.0)

5.0 (1–11)

4.0 (1.0–11.0)

6.0 (0–10)

0.3

APACHE II

         

   Pentaglobin®

15.0 (9–24)

14.0 (8.0–28.0)

14.0 (7–24)

13.0 (7–30)

11.0 (5.0–30.0)

11.5* (5.0–30.0)

12.5 (5.0–30.0)

8.0** (5–30)

< 0.001

   Control

16.0 (3–27)

15.5 (5.0–27.0)

16.0 (5–24)

15.0 (4–22)

11.5** (3.0–21.0)

11.0** (1.0–27.0)

11.0** (1.0–21.0)

11.0** (1–16)

< 0.001

  1. Values are expressed as median (range). ANOVA, analysis of variance; APACHE II, acute physiological and chronic health evaluation; PCT, procalcitonin; SOFA, sequential organ failure assessment. *P < 0.05, **P < 0.01 when compared to Day 1.