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Table 2 Some interventions that have not been shown to be useful in large multicenter trials targeting mortality.

From: Paradigm shifts in critical care medicine: the progress we have made

• Tight blood glucose control

• Growth hormone

• Intraaortic balloon counterpulsation

• ScvO2 monitoring

• Glutamine administration

• Blood transfusions

• Albumin solutions

• Steroids in septic shock

• Early parenteral nutrition

• NOS inhibitor in septic shock

• Hemoglobin solution in polytrauma

• HES solutions for fluid therapy

• Glutamine supplementation

• Beta-stimulants in ARDS

• Activated protein C in sepsis

• Bicarbonate in metabolic acidosis

• High-frequency ventilation in ARDS

• Antioxidant supplementation

• Craniectomy in severe brain injury

• Talactoferrin in sepsis

• Embolectomy in stroke

• Pulmonary artery catheter

  1. ARDS acute respiratory distress syndrome, HES hydroxyethyl starch, NOS nitric oxide synthase, ScvO 2 central venous oxygen saturation