Figure 3
From: Bench-to-bedside review: Toll-like receptors and their role in septic shock
The intracellular signaling pathways of the Toll-like receptor 4 (TLR4) complex. IKB, inhibitory subunit κB; IKK, I-κB kinase; IRAK, IL-1 receptor-associated kinase; LBP, lipopolysaccharide binding protein; LPS, lipopolysaccharide; Mal, myeloid differentiation factor MyD88-like; MyD88, myeloid differentiation factor; NF-κB, nuclear factor-κB; NIK, nuclear factor-κB inducing kinase; PKR, RNA binding protein kinase; TIR, Toll IL-1 receptor; TIRAP, Toll IL-1 receptor adapter protein; Tollip, Toll interactive protein; TRAF6, tumor necrosis factor receptor-associated factor 6.