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Table 4 Sedatives used in status asthmaticus

From: Clinical review: Severe asthma

Agents Dose Side effects
Peri-intubation period   
   Midazolam 1 mg (intravenous) slowly, every 2–3 min until the patient allows positioning and airways inspection Hypotension, respiratory depression
   Ketamine 1–2 mg/kg (intravenous) at a rate of 0.5 mg/kg/min Sympaticomimetics effects, delirium
   Propofol 60–80 mg/min initial intravenous infusion up to 2.0 mg/kg, followed by an infusion of 5–10 mg/kg/hour as needed Respiratory depression
Mechanical ventilation   
   Midazolam 1–10 mg/hour continuous intravenous infusion  
   Morphine sulfate 1–5 mg/hour intravenous continuous infusion Nausea, vomiting, ileus
   Ketamine 0.1–0.5 mg/min (intravenous)  
   Propofol 1–4.5 mg/kg/hour (intravenous) Seizures, hyperlipidemia