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Table 1

From: PK/PD of single-dose amikacin in emergency department patients with severe sepsis/shock: should we apply the ICU-based higher loading dose?

PK parameter

15 mg/kg ED

25 mg/kg ED

25 mg/kg ICU

Peak (mg/l)

58(47 to 70)a

91(72 to 105)a

73(62 to 90)

Trough (mg/l)

6(3 to 12)

5(3 to 15)

7(2 to 15)

Vd (l/kg)

0.3(0.3 to 0.5)

0.4(0.2 to 0.6)

0.4(0.3 to 0.5)

Cl (ml/minute/kg)

1.6(1 to 2.3)a

2.2(1.4 to 3)a

1.9(1.3 to 3.5)

  1. Cl, clearance. aMann-Whitney U <0.05 15 versus 25 mg/kg ED patients.
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Critical Care

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