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Table 1 %GE, GC, serum cytokine levels (pg/ml) and colonic cytokine levels (pg/g colon) in mice that underwent splenectomy or sham surgery, followed by the CLP procedure and administration of vehicle or 8 mg/kg GTS-21

From: Effects of splenectomy and GTS-21, a selective α7 nicotinic acetylcholine receptor agonist, on the development of septic ileus in mice

GI transit study (n= 11) %GE GC
Nonseptic animals 88.96 ± 8.13 4.86 ± 0.45
Sham + vehicle + CLP 53.27 ± 10.32 2.53 ± 0.42
Sham + GTS-21 8 mg/kg + CLP 83.62 ± 5.91* 4.26 ± 0.35*
SPLX + vehicle + CLP 79.49 ± 8.98* 3.86 ± 0.44*
SPLX + GTS-21 8 mg/kg + CLP 77.64 ± 11.81* 3.55 ± 0.52
Cytokine level in serum ( n = 8 to 11) IL-6 TNFα
Nonseptic animals 2.57 ± 0.48 4.95 ± 0.29
Sham + vehicle + CLP 243.56 ± 54.89 63.72 ± 21.25
Sham + GTS-21 8 mg/kg + CLP 90.26 ± 31.31* 54.23 ± 25.14
SPLX + vehicle + CLP 74.31 ± 17.45* 11.52 ± 1.99#
SPLX + GTS-21 8 mg/kg + CLP 64.98 ± 7.15* 12.81 ± 3.91#
Cytokine levels in colonic tissue ( n = 5 to 11) IL-6 TNFα
Nonseptic animals 20.43 ± 4.87 41.30 ± 4.47
Sham + vehicle + CLP 1281.85 ± 932.10 137.15 ± 61.36
Sham + GTS-21 8 mg/kg + CLP 134.88 ± 36.15 46.46 ± 5.03*
SPLX + vehicle + CLP 214.22 ± 75.88 29.97 ± 8.60*
SPLX + GTS-21 8 mg/kg + CLP 487.49 ± 343.87 46.03 ± 17.22*
  1. Data presented as mean ± SEM. Two-way ANOVA or one-way ANOVA as appropriate with SNK post hoc testing; *P ≤ 0.05 versus sham + vehicle, #P ≤ 0.05 significant effect of splenectomy (SPLX).