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Table 1 Characteristics of sepsis patients and hospital controls

From: Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients

  Sepsis with shock Sepsis no shock Hospital controls Sepsis shock versus no shock All sepsis versus control
Subjects, n 12 12 12   
Age, years 52 (45 to 57) 45 (39 to 55) 49 (40 to 56) ns ns
Male, n (%) 7 (58%) 6 (50%) 8 (67%) ns ns
ATSI, n (%) 10 (83%) 7 (58%) 8 (67%) ns ns
APACHE II score, day 0 20 (29 to 23) 8 (4 to 14)   <0.0001 N/A
SOFA score, day 0 10 (4 to 10) 1 (0 to 2)   <0.0001 N/A
Plasma L-arginine, μM 39 (25 to 53) 40 (21 to 48) 74 (65 to 88) ns <0.0001
Plasma IL-6, pg/mL 1433 (400 to 4290) 82 (42 to 302) 5 (5 to 5) <0.0001 <0.0001
Plasma IL-10 (pg/mL), median (range) 65 (5 to 9525) 5 (5 to 72) 5 (5) 0.001 0.004
Plasma VEGF, pg/mL 89 (16 to 115) 79 (62 to 138) 51 (32 to 71) ns 0.03
Plasma arginase, μmol/mL/hr 0.18 (0.1 to 0.23)* 0.19 (0.12 to 0.26) 0.14 (0.09 to 0.16) ns ns
Interphase-neutrophils (%) 19.2 (4.4 to 29.5) 2.7 (1.5 to 6.1) 1.5 (0 to 2.0) 0.02 0.001
Neutrophil × 103/μL 13.1 (7.2 to 19.4) 14.2 (11.4 to 16.6) 6 (4.0 to 9.6) ns 0.02
Imm. granulocyte × 103/μL, median (range) 0.4 (0 to 11.8) 0 (0 to 7.6) 0 (0 to 0) 0.05 N/A
Monocyte × 103/μL 0.45 (0.1 to 1.2) 0.65 (0.4 to 1) 0.55 (0.5 to 0.7) ns ns
Lymphocyte × 103/μL 1.2 (0.5 to 2.1) 1.2 (0.8 to 1.6) 2.2 (1.5 to 2.4) ns ns
Causative organism, n (%)      
None cultured 5 (42%) 9 (75%)    
Gram-positive bacteria 4 (33%) 2 (17%)    
Gram-negative bacteria 3 (25%) 1 (8%)    
  1. Values show the median (interquartile range) unless stated otherwise. *n = 11, Interphase neutrophil (%) indicates the proportion of neutrophils in the total interphase layer (gated per Figure 1A). ATSI, Aboriginal or Torres Strait Islander; APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; VEGF, vascular endothelial growth factor; N/A, not assessed; ns, not significant.