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Figure 2 | Critical Care

Figure 2

From: Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients

Figure 2

Inverse association between T cell zeta-chain expression and interphase neutrophil number. (A) Gated T cell CD3 zeta-chain expression ex vivo in patients with septic shock (n = 12), sepsis without shock (n = 12), and hospital controls (n = 12) on day 0 (enrolment). (B) On day 2, zeta-chain expression remained low in septic shock patients but recovered for non-shocked patients. Horizontal lines show the median and interquartile range. (C) Inverse association between the proportion of ex vivo interphase neutrophils and T cell zeta-chain expression in patients with septic shock (n = 11) on day 0. (D) Longitudinal ex vivo CD3 zeta-chain expression (left axis, filled circles) and the percentage of interphase neutrophils (right axis, empty circles) in three representative patients with septic shock. This longitudinal inverse association was statistically significant in a mixed effects model (P = 0.02).

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