Experimental and clinical evidences for glucose control in intensive care: is infused glucose the key point for study interpretation?

Table 3 Summary of characteristics from the different major trials about glucose-insulin treatment

Study name	VDB 2001[4]		VDB 2006[11]		Glucontrol[10]		NICE-SUGAR[5]		COITTSS[7]		VISEP[50]
	Experimental	Control	Experimental	Control	Experimental	Control	Experimental	Control	Experimental	Control	Experimental	Control
Morning mean BGL, mg/dL	103.6	154.5	110.0	160.9	110.9	140.0	118.0	144.9	147.3	154.5	112.7	152.7
SD or confidence interval	20.0	32.7	30.0	28.0	100-123.6	121.8- 160	25.1	26.0	30.9	34.5	1.8	3.6
Death at 90 days, %	5	7	35.9	37.7	23.3	19.4	27.5	24.9	45.9	42.9	39.7	35.4
Caloric intake, kcal/day	550-1,600		1,202	1,237	760	760	891	872	1,350		1,217	1,253
Quantity of glucose administered per day, g	120		202	198	73.7	71.8	23.4	24.4	25		144	144
Daily insulin dose, insulin units	71	33	59	10	31.2	7.68	50.2	16.9	71	46	43	29
SD or confidence interval	48-100	17-56	37-86	0-38	15.6- 55.2	30.48	38.1	29	45-96	30-65	23-64	15-51
Hypoglycemia rate, %	0.8	5	18.7	3.1	8.7	2.7	6.8	0.5	16.4	7.8	10.1	4.1

BGL, blood glucose level; COITTSS, Corticosteroids and Intensive Insulin Therapy for Septic Shock; NICE-SUGAR, Normoglycemia in Intensive Care Evaluation and Surviving Using Glucose Algorithm Regulation; SD, standard deviation; VDB, Van den Berghe; VISEP, Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis.

ISSN: 1364-8535