Table 3 Clinical outcomes according to sedation depth
Clinical outcomes | All patients (n = 322) | Light sedation (n = 209) | Deep sedation (n = 113) | Pvaluea |
|---|---|---|---|---|
Respiratory data | ||||
ARDS mild | 50 (15.5) | 35 (16.7) | 15 (13.3) | 0.521 |
ARDS moderate/severe | 49 (15.2) | 35 (16.7) | 14 (12.4) | |
PO2/FiO2 ratio | 278 (208 to 339) | 268 (208 to 329) | 282 (208 to 353) | 0.486 |
Tracheostomy | 90 (28.3) | 46 (22) | 44 (38.9) | 0.001 |
Extubation failure | 42 (13.8) | 32 (15.3) | 10 (8.8) | 0.119 |
Length of ventilatory support (days) | 5 (3 to 9) | 5 (3 to 9) | 7 (4 to 10) | 0.041 |
Ventilator-free days | 17.5 (0 to 23.3) | 21 (0 to 25) | 0 (0 to 21) | <0.001 |
ICU support | ||||
Renal replacement therapy | 69 (21.7) | 54 (25.8) | 15 (13.3) | 0.008 |
Vasopressors | 247 (77.4) | 162 (77.5) | 85 (75.2) | 0.629 |
Outcomes | ||||
ICU length of stay (days) | 11 (6 to 19) | 11 (6 to 19) | 11 (6 to 18) | 0.633 |
Hospital length of stay (days) | 20 (12 to 34) | 21 (13 to 35.8) | 19 (10 to 27) | 0.084 |
ICU mortality | 98 (30.4) | 56 (26.8) | 42 (37.2) | 0.054 |
Hospital mortality | 125 (38.8) | 73 (34.9) | 52 (46) | 0.051 |