Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study

Table 4 Distributions of continuous parameters in relation to linezolid target ranges

	Median and range of patients
	AUC₂₄(mg*h/L)^a			C_min(mg/L)^b
Patient groups	<200	200 to 400	>400	<2	2 to 10	>10
Mean creatinine clearance (mL/minute)^c
median	89	62		89	70
range	35 to 163	21 to 117		35 to 163	21 to 117
(number of patients)	(17)	(8)		(15)	(10)
APACHE II score
median	28	24	32	28	24	32
range	12 to 37	9 to 33	28 to 35	12 to 37	9 to 33	28 to 35
(number of patients)	(19)	(9)	(2)	(15)	(13)	(2)
Age (years)
median	53	59	56	57	57	56
range	28 to 77	34 to 84	50 to 61	28 to 77	29 to 84	50 to 61
(number of patients)	(19)	(9)	(2)	(15)	(13)	(2)
Body mass index (kg/m²)
median	24	19	21	22	23	21
range	13 to 32	17 to 26	19 to 23	13 to 32	17 to 28	19 to 23
(number of patients)	(19)	(9)	(2)	(15)	(13)	(2)

^aAs determined by the NONMEM system, values from the start of the third administration of linezolid; ^bas determined by liquid chromatography tandem mass spectrometry, values obtained directly before the fourth administration of linezolid; ^cmean value of the 4 study days. AUC₂₄, concentration time curve over 24 h; C_min, linezolid trough level; APACHE II, acute physiology and chronic health evaluation II.

ISSN: 1364-8535