Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study

Table 1 Characteristics of the study population

Patient number	APACHE II score	Mean creatinine clearance (ml/minute)^a	CRRT (+/-)	ECLA (+/-)	Organ transplantation^b	Clinical condition
1	20	89	-	+	Lung	Septic pneumonia
2	12	129	-	-	-	ARDS
3	20	21	-	-	-	Septic peritonitis
4	28	114	-	-	-	Septic pleural empyema
5	23	97	-	+	-	ARDS
6	33	72	-	+	-	Septic pneumonia
7	9	117	-	-	Lung	Septic pneumonia
8	28	119	-	-	Lung	Septic pneumonia
9	28	-	+	-	Liver	Septic peritonitis
10	29	94	-	-	-	Septic pneumonia
11	33	35	-	-	Lung	Septic pneumonia
12	31	102	-	+	-	Septic pneumonia
13	14	127	-	-	-	Septic pneumonia
14	14	69	-	-	Lung	Septic pneumonia
15	32	42	-	-	-	Septic endocarditis
16	19	76	-	+	-	Septic pneumonia
17	35	-	+	-	Liver	Septic peritonitis
18	21	33	-	-	Lung	Septic pneumonia
19	27	55	-	-	Lung	Septic pneumonia
20	17	64	-	-	Lung	Septic pleural empyema
21	30	68	-	-	-	Septic pneumonia
22	23	-	+	-	Liver	Septic peritonitis
23	14	85	-	-	Liver	Septic peritonitis
24	24	-	+	-	Liver	Septic peritonitis
25	37	74	-	-	Lung	Septic pneumonia
26	25	83	-	+	Lung	Septic pneumonia
27	28	-	+	-	-	Septic peritonitis
28	34	163	-	+	-	Septic pneumonia
29	32	126	-	-	-	ARDS
30	29	37	-	-	-	Septic peritonitis
Median	27.5	83
(range)	(9 to 37)	(21 to 163)

^aMean value of the 4 study days; ^bwithin the last 28 days. APACHE II, acute physiology and chronic health evaluation II score; CRRT, continuous renal replacement therapy; ECLA, extracorporeal lung assist; ARDS, acute respiratory distress syndrome.

ISSN: 1364-8535