Endogenous thrombin potential following hemostatic therapy with 4-factor prothrombin complex concentrate: a 7-day observational study of trauma patients

Table 1 Clinical and demographic data upon emergency room admission

	NCT group	FC group	FC-PCC group	P-values
				FC-PCC versus NCT	FC-PCC versus FC
ISS	18.8 ± 9.4	29.0 ± 11.0	35.7 ± 13.0	<0.0001	ns
Age, years	46 ± 17	40 ± 14	36 ± 13	0.028	ns
Hb, g/dL	12.8 ± 2.2	12.6 ± 2.0	10.1 ± 2.6	0.0002	0.002
Platelet count × 10³/μL	225 ± 59	210 ± 54	191 ± 39	0.0334	ns
PT, sec	13.7 (12.7 to 14.6)	14.6 (13.8 to 15.2)	17.2 ± 3.1	0.0002	0.003
aPTT, sec	26.6 (24.5 to 29.1)	27.9 ± 3.2	34.8 ± 9.9	0.0034	0.0042
AT, %	87 ± 16	83 ± 14	61 ± 15	<0.0001	ns
Fibrinogen, mg/dL	234 (197 to 324)	196 ± 52	163 ± 60	<0.0001	0.0001
pH	7.34 (7.29 to 7.37)	7.35 ± 0.07	7.32 ± 0.08	ns	ns
BD, mmol/L	1.9 (0.1 to 3.1)	2.4 (0.8 to 5.2)	5.3 (3.9 to 8.3)	0.0035	0.024
Lactate, mmol/L	2.2 (1.3 to 3.2)	1.8 (1.2 to 3.1)	3.5 (2.3 to 5.5)	0.028	0.014

ISS, injury severity score; Hb, hemoglobin; BD, base deficit; ns, not significant; PT, prothrombin time; aPTT, activated partial thromboplastin time; AT, antithrombin; NCT group, no coagulation therapy; FC group, fibrinogen concentrate only; FC-PCC group, prothrombin complex concentrate and fibrinogen concentrate.
Data are presented as mean ± standard deviation or median (interquartile range). P-values are derived from t-test or Mann-Whitney U-test; significance level P <0.05.

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