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Table 1 Clinical and demographic data upon emergency room admission

From: Endogenous thrombin potential following hemostatic therapy with 4-factor prothrombin complex concentrate: a 7-day observational study of trauma patients

  NCT group FC group FC-PCC group P-values
     FC-PCC versus NCT FC-PCC versus FC
ISS 18.8 ± 9.4 29.0 ± 11.0 35.7 ± 13.0 <0.0001 ns
Age, years 46 ± 17 40 ± 14 36 ± 13 0.028 ns
Hb, g/dL 12.8 ± 2.2 12.6 ± 2.0 10.1 ± 2.6 0.0002 0.002
Platelet count × 103/μL 225 ± 59 210 ± 54 191 ± 39 0.0334 ns
PT, sec 13.7 (12.7 to 14.6) 14.6 (13.8 to 15.2) 17.2 ± 3.1 0.0002 0.003
aPTT, sec 26.6 (24.5 to 29.1) 27.9 ± 3.2 34.8 ± 9.9 0.0034 0.0042
AT, % 87 ± 16 83 ± 14 61 ± 15 <0.0001 ns
Fibrinogen, mg/dL 234 (197 to 324) 196 ± 52 163 ± 60 <0.0001 0.0001
pH 7.34 (7.29 to 7.37) 7.35 ± 0.07 7.32 ± 0.08 ns ns
BD, mmol/L 1.9 (0.1 to 3.1) 2.4 (0.8 to 5.2) 5.3 (3.9 to 8.3) 0.0035 0.024
Lactate, mmol/L 2.2 (1.3 to 3.2) 1.8 (1.2 to 3.1) 3.5 (2.3 to 5.5) 0.028 0.014
  1. ISS, injury severity score; Hb, hemoglobin; BD, base deficit; ns, not significant; PT, prothrombin time; aPTT, activated partial thromboplastin time; AT, antithrombin; NCT group, no coagulation therapy; FC group, fibrinogen concentrate only; FC-PCC group, prothrombin complex concentrate and fibrinogen concentrate.
  2. Data are presented as mean ± standard deviation or median (interquartile range). P-values are derived from t-test or Mann-Whitney U-test; significance level P <0.05.