Prothrombin time, activated partial thromboplastin time, fibrinogen concentration and antithrombin activity from emergency room (ER) admission until day 7. The prothrombin complex concentrate-fibrinogen concentrate group (FC-PCC group) (dark gray) was compared with the fibrinogen concentrate group (FC group) (light gray) and patients receiving no coagulation therapy (NCT group) (white). *P <0.05; **P <0.01; ***P <0.001; ****P <0.0001; no indication = not significant. Data are presented as box and whisker plots (Tukey). Student t-test or Mann-Whitney rank sum test was used as appropriate for between-group comparisons.