TY - JOUR AU - Marion, Donald W. AU - Regasa, Lemma E. PY - 2014 DA - 2014/06/30 TI - Revisiting therapeutic hypothermia for severe traumatic brain injury… again JO - Critical Care SP - 160 VL - 18 IS - 3 AB - Improved understanding of the molecular mechanisms of secondary brain injury has informed the optimum depth and duration of cooling and led to increased clinical interest in the therapeutic moderate hypothermia for severe traumatic brain injury over the past two decades. Although several large multi-center clinical trials have not found a treatment effect, multiple single-center trials have, and a recent meta-analysis by Crossley and colleagues now finds that the cumulative findings of those single-center trials dilute the multi-center trial results and show an overall reduction in mortality and poor outcomes associated with cooling. The need for consistent support of key physiologic parameters during cooling is emphasized by this finding. SN - 1364-8535 UR - https://doi.org/10.1186/cc13955 DO - 10.1186/cc13955 ID - Marion2014 ER -