Treatment for infections with carbapenem-resistant Enterobacteriaceae: what options do we still have?

Table 2 Dosing recommendations for colistin-based products available for parenteral use in critically ill patients

Region	Product type^a	Dose recommended
US	Colistin base activity	Loading dose: 270 mg colistin base
US	(150 mg vials)	Maintenance dose: 135 mg colistin base every 12 hours
Other	Colistimethate sodium	Loading dose: 9 million IU
	(1 and 2 million IU vials)	Maintenance dose: 4.5 million IU every 12 hours

^a30 mg colistin base activity = 1 million IU colistimethate sodium = approximately 80 mg colistimethate sodium [15, 17]. These doses are based on normal renal function; renal adjustment is indicated for creatinine clearance of less than 50 mL/minute [17].

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