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Table 4 Severity of H1N1pdm infection in hospitalized patients regarding haplotypes of SFTPA2

From: Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection

    

Statistical significance

   

P a

P b

P a

P b

   

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Haplotype

Diplotype frequencies

Diplotype comparisons

Haplotype comparisons

1A 0 (AGC)

1A 0 /1A 0

1A 0 /rest

Rest/rest

1A 0 /1A 0 vs 1A 0 /rest + rest/rest

1A 0 vs rest

 ARF

48

16 (0.33)

27 (0.56)

5 (0.10)

0.031

0.045

0.023

0.022

 No ARF

22

2 (0.09)

14 (0.64)

6 (0.27)

5.00 (1.04-24.10)

6.38 (1.04-38.97)

2.30 (1.11-4.76)

2.81 (1.16-6.77)

 ARDS

16

8 (0.50)

7 (0.44)

1 (0.06)

0.020c

0.013

0.029

0.016

 No ARDS

54

10 (0.19)

34 (0.63)

10 (0.19)

4,40.(1.33-14.56)

5.44 (1.43-20.77)

2.56 (1.08-6.02)

3.41 (1.26-9.22)

 MV

24

11 (0.46)

12 (0.50)

1 (0.04)

0.005

0.004

0.007

0.003

 No MV

46

7 (0.15)

29 (0.63)

10 (0.22)

4.72 (1.51-14.69)

7.03 (1.83-26.95)

2.78 (1.31-5.83)

3.73 (1.55-9.00)

1A 1 (CGA)

1A/1A 1

1A 1 /rest

rest/rest

1A1/1A1+1A1/rest vs rest/rest

1A 1 vs rest

 ARF

48

0 (0.00)

11 (0.23)

37 (0.77)

0.009

0.0017

0.004

0.005

 No ARF

22

2 (0.09)

10 (0.46)

10 (0.46)

0.25 (0.08-0.73)

0.08 (0.02-0.39)

0.23 (0.11-0.68)

0.21 (0.07-0.62)

 ARDS

16

0 (0.00)

2 (0.12)

14 (0.88)

-

0.040

-

0.021

 No ARDS

54

2 (0.04)

19 (0.35)

33 (0.61)

-

0.16 (0.03- 0.92)

-

0.12 (0.02-0.73)

 MV

24

0 (0.00)

4 (0.17)

20 (0.83)

0.037

0.019

0.034

0.015

 No MV

46

2 (0.04)

17 (0.37)

27 (0.59)

0.28 (0.08-0.97)

0.08 (0.01-0.66)

0.31 (0.1-0.96)

0.16 (0.04-0.70)

 ICUe

30

0 (0.00)

4 (0.13)

26 (0.87)

0.003

0.015

0.003

0.029

 No ICUe

40

2 (0.05)

17 (0.43)

21 (0.53)

0.17 (0.05-0.58)

0.25 (0.08-0.76)

0.20 (0.07-0.62)

0.32 (0.11-0.89)

  1. Only those comparisons with P < 0.05 and significant odds ratio were included. OR (95% CI), odds ratio (95% confidence interval); ARF, acute respiratory failure; ARDS, acute respiratory distress syndrome; MV, mechanical ventilation; ICU, intensive care unit.
  2. aP value for the bivariate comparison calculated with the χ2 test. b + - + value for the multivariate analysis calculated with binary logistic regression, including the variables age, gender, risk factors, secondary bacterial pneumonia, and bacteremia. cP value by Fisher Exact test. dP value for the multivariate analysis calculated with binary logistic regression, including the variables age, gender, risk factors, and secondary bacterial pneumonia (bacteremia variable was excluded because it shows a co-lineal relation with the variable mechanical ventilation). ePatients who required (ICU) or did not require (No ICU) ICU admission, P value for the multivariate analysis calculated with conditional logistic regression stratified by hospital of origin, including the covariables age, gender, risk factors, secondary bacterial pneumonia, and bacteremia. Conventional haplotypes at SFTPA2 were identified on the basis of combinations of the polymorphism rs1059046 (T9N), rs17886395 (A91P), and rs1965708 (Q223K). “Rest” refers to the other haplotypes for each comparison.