Characteristic | Linezolid (n = 101) | Vancomycin (n = 87) | P value |
---|---|---|---|
Male, n (%) | 63 (62.4) | 49 (56.3) | 0.457 |
Hospitalization ≥5 days before therapy for VAP, n (%) | 74 (73.3) | 50 (57.5) | 0.030 |
Bronchiectasis, n (%) | 8 (7.9) | 1 (1.1) | 0.039 |
Colonization with MDRO, n (%) | 34 (33.7) | 32 (36.8) | 0.759 |
Hospitalization ≥2 days in previous 90 days, n (%) | 20 (19.8) | 17 (19.5) | 1.000 |
Nursing home resident, n (%) | 6 (5.9) | 5 (5.7) | 1.000 |
Home infusion therapy, n (%) | 2 (2.0) | 0 | 0.500 |
Home wound care, n (%) | 5 (5.0) | 3 (3.4) | 0.727 |
Active malignancy, n (%) | 8 (7.9) | 5 (5.7) | 0.774 |
End-stage liver disease, n (%) | 9 (8.9) | 1 (1.1) | 0.022 |
COPD, n (%) | 15 (14.9) | 8 (9.2) | 0.271 |
Steroid use, n (%) | 4 (4.0) | 7 (8.0) | 0.351 |
Risk factors for MDROs, n (%) | 88 (87.1) | 70 (80.5) | 0.236 |
Cardiac disease, n (%) | 29 (28.7) | 25 (28.7) | 1.000 |
Renal disease, n (%) | 8 (7.9) | 6 (6.9) | 1.000 |
Vascular disease, n (%) | 20 (19.8) | 27 (31.0) | 0.092 |
End-stage renal disease and/or dialysis, n (%) | 4 (4.0) | 3 (3.4) | 1.000 |
Diabetes, n (%) | 29 (28.7) | 17 (19.5) | 0.174 |
Respiratory disease, n (%) | 24 (23.8) | 18 (20.7) | 0.726 |
Multilobar infiltrates, n (%) | 39 (38.6) | 25 (28.7) | 0.168 |
Severe sepsis, n (%) | 78 (77.2) | 55 (63.2) | 0.038 |
Appropriate empiric antimicrobial therapy, n (%) | 100 (99.0) | 85 (97.7) | 0.597 |
Age, median (IQR) | 59 (20) | 56 (26) | 0.246 |
Body mass index, median (IQR) | 28.7 (11.9) | 27.7 (9.9) | 0.359 |
CPIS at diagnosis, median (IQR) | 6 (3) | 6 (2) | 0.177 |
CPIS at day 3, median (IQR) | 7 (3) | 7 (3) | 0.051 |
APACHE II score, median (IQR) | 21 (11) | 19 (9) | 0.041 |
Platelet count at diagnosis, median (IQR) | 219 (143) | 204 (115.5) | 0.397 |
Hemoglobin at diagnosis, median (IQR) | 9.5 (1.9) | 10 (2.1) | 0.026 |
Creatinine clearance at diagnosis, median (IQR) | 78.5 (59.3) | 95.9 (69.3) | 0.054 |
Vancomycin MIC (μg/mL, E-test), n (%) | 0.087 | ||
0.75 | 1 (2.4) | 0 | |
1 | 5 (11.9) | 0 | |
1.5 | 22 (52.4) | 26 (72.2) | |
2 | 14 (33.3) | 10 (27.8) | |
Vancomycin serum trough level (μg/mL), | |||
mean ± SD | |||
Day 3 | … | 13 ± 8 | |
Overall | … | 21 ± 11 |