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Table 4 Univariate analysis comparing survivors and nonsurvivors in the septic patient cohort

From: Prognostic and diagnostic value of eosinopenia, C-reactive protein, procalcitonin, and circulating cell-free DNA in critically ill patients admitted with suspicion of sepsis

 

Survivors (n = 76)

Deaths (n = 41)

P value

Demographic variables

   

  Gender (female)

39 (51.3)

13 (31.7)

0.042

  Age

63 (52 to 73)

66 (52 to 74)

0.301

Underlying diseases

   

  Diabetes

14 (18.4)

9 (22)

0.647

  Cirrhosis

1 (1.3)

4 (9.8)

0.050

  ESRD

6 (7.9)

4 (9.8)

0.739

  Immunosuppression

10 (13.2)

6 (14.6)

0.825

  Cancer

4 (5.3)

11 (26.8)

0.001

  Chronic cardiac insufficiency

5 (6.6)

2 (4.9)

0.998

  COPD

9 (11.8)

7 (17.1)

0.432

SIRS

   

  Two SIRS criteria

21 (27.6)

8 (19.5)

0.027

  Three SIRS criteria

28 (36.8)

8 (19.5)

 

  Four SIRS criteria

27 (35.5)

25 (61)

 

Severity scores

   

  APACHE II

16 (12 to 22)

22 (16 to 27)

0.001

  SOFA

7 (4 to 11)

10 (6 to 13)

0.007

Laboratory parametersa

   

  Leukocytes day 1

13,035 (9,565)

14,340 (12,730)

0.591

  Leukocytes day 2

14,345 (8,208)

17,780 (12,665)

0.010

  Eosinophils day 1

50.13 (11.80)

83.41 (35.83)

0.055

  Eosinophils day 2

82.23 (14.65)

123.24 (52.62)

0.747

  CRP day 1

30.41 (15.77)

23.32 (20.91)

0.101

  CRP day 2

29.84 (18.36)

30.72 (20.11)

0.794

  PCT day 1

13.50 (45.26)

15.07 (57.42)

 

  PCT day 2

8.34 (22.55)

12.13 (40.47)

 

  cf-DNA day 1

5,490 (5,080)

6,660 (7,745)

0.495

  cf-DNA day 2

4,830 (6,135)

5,460 (5,400)

0.890

Source of infection

   

  Surgical

40 (52.6)

29 (70.7)

0.058

  Nosocomial

28 (36.8)

16 (39)

0.816

  Respiratory

17 (22.4)

8 (19.5)

0.719

  Urinary

12 (15.8)

2 (4.9)

0.134

  Abdominal

35 (46.1)

18 (43.9)

0.824

  Central nervous system

1 (1.3)

0

0.999

  Soft tissues

5 (6.6)

4 (9.8)

0.718

  Bacteriemic

22 (28.9)

14 (31.4)

0.561

  Unknown

3 (3.9)

2 (4.9)

0.999

  Others

3 (3.9)

7 (17.1)

0.032

Outcomes

   

  Length of stay in ICU

8 (4 to 18)

6 (3 to 14)

0.089

  Length of stay in hospital

26 (18 to 43)

12 (5 to 22)

<0.001

  1. Data presented as n (%) or median (interquartile range). APACHE, Acute Physiology and Chronic Health Evaluation; ARF, acute renal failure; cf-DNA, cell-free DNA; COPD, chronic obstructive pulmonary disease; CRP, C-reactive protein; ESRD, end-stage renal disease; PCT, procalcitonin; SIRS, systemic inflammatory response syndrome; SOFA, Sequential Organ Failure Assessment. aFor comparison, nonparametric tests were used.