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Table 1 Baseline characteristics of the inception cohort

From: Prognostic and diagnostic value of eosinopenia, C-reactive protein, procalcitonin, and circulating cell-free DNA in critically ill patients admitted with suspicion of sepsis

 

Total cohort (n = 160)

SIRS patients (n = 43)

Sepsis patients (n = 117)

P valuea

Demographic variables

    

  Gender (female)

81 (50.6)

29 (67.4)

52 (44.4)

0.010

  Age

63 (51 to 74)

63 (48 to 75)

63 (52 to 73)

0.846

Underlying disease

    

  Diabetes

35 (21.9)

12 (27.9)

23 (19.7)

0.263

  Cirrhosis

6 (3.8)

1 (2.3)

5 (4.3)

0.565

  ESRD

12 (7.5)

2 (4.7)

10 (8.5)

0.407

  Immunosuppression

20 (12.5)

16 (13.7)

4 (9.3)

0.458

  Cancer

20 (12.5)

5 (11.6)

15 (12.8)

0.840

  Chronic cardiac insufficiency

11 (6.9)

4 (9.3)

7 (6)

0.462

  COPD

22 (13.8)

6 (14)

16 (13.7)

0.964

SIRS

    

  Two SIRS criteria

41 (25.6)

12 (27.9)

29 (24.8)

0.036

  Three SIRS criteria

57 (35.6)

21 (48.8)

36 (30.8)

  Four SIRS criteria

62 (38.8)

10 (23.3)

52 (44.4)

Severity scores

    

  APACHE II

17 (12 to 24)

16 (11 to 22)

17 (13 to 24)

0.057

  SOFA

7 (4 to 11)

4 (1 to 9)

8 (5 to 11)

<0.001

  Worst SOFA

8 (5 to 13)

5 (2 to 9)

9 (6 to 13)

<0.001

Laboratory parameters b

    

  Leukocytes day 1

13,130 (10,185)

12,780 (8,690)

13,160 (11,280)

0.079

  Leukocytes day 2

14,700 (8,650)

12,910 (8,260)

15,395 (7,903)

0.056

  Eosinophils day 1

55.6 (11.2)

38.3 (10.6)

61.8 (14.7)

0.434

  Eosinophils day 2

91.1 (15.6)

95.6 (19.8)

78 (21.1)

0.533

  CRP day 1

26.56 (21.91)

19.5 (25.52)

28.39 (20.98)

0.002

  CRP day 2

28.85 (19.66)

23.39 (27.21)

30.2 (19.17)

0.003

  PCT day 1

7.81 (34.91)

0.73 (1.49)

13.57 (45.87)

<0.001

  PCT day 2

4.82 (20.56)

0.97 (2.58)

10.35 (25.62)

<0.001

  cf-DNA day 1

5,265 (5,377)

4,170 (4,590)

5,770 (5,420)

0.081

  cf-DNA day 2

4,895 (5,612.5)

4,490 (5,390)

5,090 (5,785)

0.417

   cf-DNA day 1, without ARFc

5,050 (5,130)

4,105 (4,502)

5,760 (5,240)

0.106

   cf-DNA day 2, without ARFc

4,960 (5,410)

3,700 (5,210)

5,410 (5,482)

0.077

Outcomes

    

  Length of stay on ICU

7.5 (4 to 14)

6 (3 to 14)

8 (4 to 15)

0.420

  ICU mortality

45 (28.1)

13 (30.2)

32 (27.4)

0.719

  Hospital mortality

57 (35.6)

16 (37.2)

41 (35)

0.800

  1. Data presented as n (%) or median (interquartile range). APACHE, Acute Physiology and Chronic Health Evaluation; ARF, acute renal failure; cf-DNA, cell-free DNA; COPD, chronic obstructive pulmonary disease; CRP, C-reactive protein; ESRD, end-stage renal disease; PCT, procalcitonin; SIRS, systemic inflammatory response syndrome; SOFA, Sequential Organ Failure Assessment. aP values for comparisons between SIRS and septic groups. bFor comparison, nonparametric tests were used. cARF defined as renal SOFA ≥3 (n = 34).
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