| Baseline | D0 | D1 | D2 | D3 | |||||
---|---|---|---|---|---|---|---|---|---|---|
Systemic haemodynamics | Nonsevere complications | Severe complications | Nonsevere complications | Severe complications | Nonsevere complications | Severe complications | Nonsevere complications | Severe complications | Nonsevere complications | Severe complications |
Heart rate (beats/min) | 74 (1) | 76 (4) | 77 (1) | 87 (5)b | 80 (2) | 91 (5)b | 83 (1) | 91 (4)b | 81 (2) | 92 (3)b |
Mean arterial pressure (mmHg) | 96 (2) | 95 (4) | 89 (2) | 85 (3) | 90 (2) | 87 (5) | 93 (2) | 93 (4) | 96 (1) | 91 (4) |
pH | 7.36 (0.02) | 7.41 (0.02) | 7.36 (0.01) | 7.37 (0.01) | 7.39 (0.01) | 7.39 (0.02) | 7.40 (0.02) | 7.43 (0.01) | 7.40 (0.02) | 7.43 (0.01) |
PaO2 (kPa) | 10.5 (5.8) | 11.1 (0.05) | 17.6 (0.9) | 15.8 (1.3) | 12.7 (0.5) | 11.7 (0.7) | 11.3 (0.5) | 13.6 (2.3) | 10.2 (0.6) | 11.4 (1.1) |
Base excess | -4.0 (2.08) | -3.0 (3.0) | -2.92 (0.29) | -2.69 (1.08) | -2.20 (0.34) | -2.0 (1.06) | -0.59 (0.47) | -0.36 (1.59) | -0.22 (0.85) | 0.5 (1.29) |
Lactate (mmol/L) | 1.3 (0.2) | 1.6 (0.01) | 1.3 (0.1) | 1.6 (0.3) | 1.2 (0.1) | 1.5 (0.2) | 1.1 (0.1) | 1.1 (0.1) | 1.1 (0.1) | 1.3 (0.2) |
Haemoglobin (g/dl) | 7.7 (0.2) | 8.0 (0.3) | 7.1 (0.1) | 6.9 (0.3) | 6.8 (0.1) | 6.5 (0.3) | 6.5 (0.1) | 5.9 (0.3)b | 6.4 (0.1) | 5.8 (0.3) |
Creatinine (μmol/L) | 81 (7) | 85 (12) | 84 (6) | 94 (13)b | 76 (5) | 89 (10)b | 69 (5) | 86 (9) | 68 (6) | 82 (10) |
C-reactive protein (mg/L) | 8 (2) | 21 (18) | 35 (9) | 96 (33)b | 86 (10) | 121 (26)b | 135 (15) | 156 (24) | 120 (15) | 153 (29) |
White blood cells (109/L) | 6.7 (0.3) | 9.7 (2.5) | 8.7 (0.4) | 10.8 (1.4) | 11.6 (0.5) | 11.5 (0.7) | 11.3 (0.4) | 11.3 (0.4) | 10.2 (0.5) | 9.7 (0.5) |
Central temperature (°C) | 36.7 (0.1) | 36.7 (0.1) | 36.7 (0.1) | 36.7 (0.1) | 37.1 (0.1) | 37.3 (0.1) | 37.0 (0.1) | 37.2 (0.1) | 37.0 (0.1) | 37.2 (0.1) |
Vasopressor use, n (%) | – | – | 36 (39) | 11 (58) | 25 (27) | 10 (52) | 9 (10) | 7 (37) | 3 (3) | 3 (16) |
Vasopressor dose (μg/kg/min) | – | – | 0.17 (0.12) | 0.07 (0.03)b | 0.05 (0.33) | 0.04 (0.02) | 0.01 (0.05) | 0.01 (0.07) | 0 | 0.18 (0.01) |