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Table 1 Characteristics of patients with critical care infections receiving versus not receiving adequate treatment within 24 hours

From: Weighted-incidence syndromic combination antibiograms to guide empiric treatment of critical care infections: a retrospective cohort study

Characteristics

Patients receiving early adequate treatment within 24 h (n = 84)

Patients not receiving early adequate treatment within 24 h (n = 79)

P-value

Age, years, median (IQR)

56 (36 to 75)

64.13 (46.25 to 76)

0.09

Male sex, n (%)

63 (75%)

57 (72%)

0.72

Admission source, n (%)

   

Emergency Room

31 (37%)

25 (32%)

0.51

Ward

14 (17%)

21 (27%)

0.13

Operating Room

17 (20%)

11 (14%)

0.31

Step-up

6 (7%)

8 (10%)

0.58

Other

16 (19%)

14 (18%)

0.84

ICU Type, n (%)

   

Medical

28 (33%)

25 (32%)

0.87

Surgical

0 (0%)

1 (1.3%)

0.48

Trauma

2 (2%)

5 (6%)

0.27

Burns

9 (11%)

7 (8.7%)

0.79

Neurosurgical

36 (43%)

30 (38%)

0.63

Cardiac

9 (11%)

11 (14%)

0.64

ICU level, n (%)

   

Level 3

84 (100%)

79 (100%)

1.00

Comorbidities, n (%)

66 (78.6%)

62 (78.5%)

1.00

Heart disease

25 (30%)

16 (20%)

0.21

Peripheral vascular

9 (10.8%)

6 (8%)

0.59

Diabetes

16 (19%)

17 (21%)

0.70

Renal disease/dialysis

13 (15.5%)

10(13%)

0.66

Hypertension

27 (32%)

29 (36%)

0.62

COPD/asthma

12 (14%)

6 (8%)

0.22

Lung disease

7 (8.3%)

11 (14%)

0.32

Gastrointestinal disease

10 (12%)

15 (19%)

0.28

Liver disease

2 (2.4%)

6 (8%)

0.16

Neurological disease

14 (16.7%)

15 (19%)

0.84

Solid organ cancer

13(15.5%)

12 (15%)

1.00

Leukemia/lymphoma

3 (11.1%)

3 (4%)

1.00

Chemotherapy/radiation

4 (15.5%)

8 (10%)

0.24

Surgery

10 (12%)

18 (23%)

0.10

Infection

2(2.4%)

7 (9%)

0.09

Multi organ dysfunction score, median (IQR)

4 (2 to 6.2)

5 (3 to 6.5)

0.76

Organisms, n (%)

   

Mono-microbial

59 (70%)

58 (73.4%)

0.73

Poly-microbial

25 (30%)

21 (26.6%)

0.73

Frequent organisms, n (%)

   

Streptococcus pneumoniae

3 (3.6%)

8 (10%)

0.12

Staphylococcus aureus

19 (23%)

17 (21.5%)

1.00

Serratia marcescens

2 (2.4%)

3 (4%)

0.67

Pseudomonas aeruginosa

22 (27%)

12 (15%)

0.12

Klebsiella pneumonia

5 (6%)

9 (11.5%)

0.27

Klebsiella oxytoca

5 (6%)

2 (2.5%)

0.44

Haemophilus influenzae

10 (12%)

5 (6.3%)

0.28

Escherichia coli

8 (9.5%)

1 (1.4%)

0.03

Enterococcus faecalis

3 (3.6%)

5 (6.3%)

0.49

Enterobacter cloacae

3 (3.6%)

5 (6.3%)

0.49

Enterobacter aerogenes

4 (4.8%)

5 (6.3%)

0.74

Coagualse-negative staphylococci

7 (8.3%)

14 (17.7%)

0.10

Citrobacter koseri

5 (6%)

0 (0%)

0.06

Other

13 (15.5%)

18 (22.8%)

0.32

Average duration of hospital admission prior to infection, days, median (IQR)

10 (5–16) Days

12 (7 to 46.5)

0.03

Previous antibiotic use in the past 90 days before hospital admission, n (%)

7 (8.4%)

8 (10%)

0.79

Previous hospital visit in the past 90 days before hospital admission, n (%)

13 (15.5%)

13 (16.5%)

1.00

  1. COPD, chronic obstructive pulmonary disease.