Is high-frequency oscillatory ventilation more effective and safer than conventional protective ventilation in adult acute respiratory distress syndrome patients? A meta-analysis of randomized controlled trials

Table 2 Main results of meta-analysis of mortality

	Studies included (n)	Case number (n)		Heterogeneity		Pooled RR (95% CI)	P
		HFOV	CMV	I²(%)	P
Mortality at 28 or 30 days	5	800	780	63.1	0.028	1.051	0.704
Mortality at 28 or 30 days	5	800	780	63.1	0.028	(0.813, 1.358)	0.704
Subgroup
Tidal volume in control group <8 ml/kg
Mandated	3	688	683	63.1	0.067	1.149	0.329
Mandated	3	688	683	63.1	0.067	(0.869, 1.519)	0.329
Not mandated	2	112	97	56.4	0.13	0.899	0.712
Not mandated	2	112	97	56.4	0.13	(0.511, 1.582)	0.712
Plateau pressure in control group <35cmH₂O
Mandated	2	290	286	14.6	0.279	1.323	0.092
Mandated	2	290	286	14.6	0.279	(0.955, 1.834)	0.092
Not mandated	3	510	494	44.7	0.164	0.942	0.665
Not mandated	3	510	494	44.7	0.164	(0.720, -1.233)	0.665
ICU mortality	3	686	685	63.3	0.066	1.218	0.160
						(0.925, 1.604)

CMV, conventional mechanical ventilation; HFOV, high-frequency oscillatory ventilation; n, number; RR, relative risk.

ISSN: 1364-8535