Table 1 Baseline patient characteristics, demographics, and infection characteristics

Age, years

Male, n (%)

Caucasian, n (%)

Body mass index, kg/m²

Body surface area, m²

Non-operative admission diagnosis, n (%)

Intensive care unit, n (%)

Renal parameters

  History of moderate to severe kidney disease, n (%)

  Serum creatinine, mg/dL^b

  Cystatin C, mg/L

  eGFR, mL/min^c

   Cockcroft-Gault

   CKD-EPI_creatinine

   CKD-EPI_{cystatin C}

   CKD-EPI_{creatinine-cystatin C}

Infectious source, n (%)^d

  Pulmonary

  Bacteremia

  Intra-abdominal

  Skin and soft tissue infection

  Musculoskeletal

  Other/unknown^e

Microbiology

  Culture positive, n (%)

  Monomicrobial

   Specific Gram-positive organisms isolated

    Coagulase-negative Staphylococcus spp.

    Methicillin-susceptible Staphylococcus aureus

    Methicillin-resistant S. aureus

    Enterococcus spp.

Vancomycin

  Loading dose used, n (%)

  Maintenance dose

   Non-weight based, mg

   Weight-based, mg/kg

   Dose between 14 and 21 mg/kg, n (%)

  Interval, n (%)

   8 hours

   12 hours

   24 hours

  Goal trough according to site of infection

   10-15 mg/L, n (%)

   15-20 mg/L, n (%)

  Trough level, mg/L