Table 4 Proportion of therapeutic drug monitoring (TDMs) with insufficient % time (T) >4 × the minimal inhibitory concentration (MIC) for various MICs
From: β-lactam antibiotic concentrations during continuous renal replacement therapy
Insufficient drug concentrations | ||||
|---|---|---|---|---|
MIC (mg/L) | Target concentrations (mg/L) | CEF (n = 9) | TZP (n = 20) | MEM (n = 44) |
32 | 128 | 8 (89) | 9 (45) | 44 (100) |
16 | 64 | 1 (11) | 4 (20) | 44 (100) |
8 | 32 | 1 (11) | 0 | 41 (93) |
4 | 16 | 1 (11) | 0 | 20 (45) |
2 | 8 | 0 | 0 | 1 (2) |
1 | 4 | 0 | 0 | 0 |
0.5 | 2 | 0 | 0 | 0 |