Table 7 Diagnostic performances of biomarkers markers in predicting severe acute pancreatitis in patients with admission modified Marshall score <2 ( N = 142) a
From: Circulating cytokines in predicting development of severe acute pancreatitis
Predictive marker and optimal cutoff point | AUC | Sensitivity (%) | Specificity (%) | LR+ | LR- | DOR |
|---|---|---|---|---|---|---|
IL-8 (>88.1 pg/ml) | 0.79 (0.68 to 0.90) | 25.6 (11.7 to 54.7) | 95.3 (90.2 to 97.8) | 6.1 (2.0 to 19.0) | 0.75 (0.54 to 1.05) | 8.1 (2.0 to 33.6) |
HGF (>3,020.1 pg/ml) | 0.83 (0.73 to 0.92) | 28.6 (11.7 to 54.7) | 95.3 (0.90 to 97.8) | 6.1 (2.0 to 19.0) | 0.75 (0.54 to 1.05) | 8.1 (2.0 to 33.6) |
G-CSF (>477.7 pg/ml) | 0.78 (0.65 to 0.90) | 35.6 (16.3 to 61.2) | 96.1 (91.2 to 98.3) | 9.1 (3.0 to 27.7) | 0.67 (0.45 to 0.99) | 13.7 (3.3 to 56.1) |
CRP (>227 mg/L) | 0.54 (0.37 to 0.70) | 7.1 (1.3 to 31.5) | 95.3 (90.2 to 97.8) | 1.5 (0.2 to 11.8) | 0.97 (0.2 to 11.8) | 1.6 (0.2 to 14.0) |
Creatinine (>141 μmol/L) | 0.62 (0.45 to 0.79) | 7.1 (1.3 to 31.5) | 99.2 (95.7 to 99.9) | 9.1 (0.6 to 37.2) | 0.94 (0.91 to 1.08) | 9.7 (0.57 to 164.2) |
Calcium (<1.91 mmol/L) | 0.74 (0.60 to 0.88) | 36.4 (15.2 to 64.6) | 94.3 (88.7 to 97.2) | 6.4 (2.2 to 18.5) | 0.68 (0.43 to 1.06) | 9.5 (2.2 to 40.2) |
G-CSF + IL-8 + HGF | 57.1 (32.6 to 78.6) | 90.6 (84.3 to 94.6) | 6.1 (3.0 to 12.3) | 0.47 (0.26 to 0.87) | 12.9 (3.8 to 43.4) |