Table 5 Diagnostic performances of interleukin 6 and hepatocyte growth factor and conventional markers in predicting severe acute pancreatitis in all patients ( N = 163) a
From: Circulating cytokines in predicting development of severe acute pancreatitis
Predictive marker with optimal cutoff point | AUC | Sensitivity (%) | Specificity (%) | LR+ | LR- | DOR |
|---|---|---|---|---|---|---|
IL-6 (>501.6 pg/ml) | 0.81 (0.72 to 0.90) | 48.0 (30.0 to 66.5) | 93.5 (88.1 to 96.5) | 7.4 (3.5 to 15.6) | 0.56 (0.38 to 0.81) | 13.2 (4.7 to 37.3) |
HGF (>3,020.1 pg/ml) | 0.87 (0.81 to 0.94) | 60.0 (40.7 to 0.77) | 92.8 (87.1 to 96.0) | 8.3 (4.2 to 16.3) | 0.43 (0.27 to 0.70) | 19.2 (6.9 to 53.6) |
IL-6 + HGF | 0.89 (0.82 to 0.96) | 72.0 (52.4 to 85.7) | 89.9 (83.7 to 93.9) | 7.1 (4.1 to 12.3) | 0.31 (0.17 to 0.59) | 22.8 (8.1 to 64.0) |
CRP (>227 mg/L) | 0.692 (0.57 to 0.82) | 40.0 (23.4 to 59.3) | 93.5 (88.0 to 96.5) | 6.1 (2.8 to 13.6) | 0.64 (0.47 to 0.89) | 9.6 (3.4 to 27.2) |
Creatinine (>141 μmol/L) | 0.76 (0.65 to 0.88) | 40.0 (23.4 to 59.3) | 96.3 (91.7 to 98.4) | 10.9 (4.1 to 29.1) | 0.62 (0.45 to 0.86) | 17.5 (5.3 to 57.9) |
Calcium (<1.91 mmol/L) | 0.81 (0.70 to 0.91) | 57.9 (36.3 to 76.9) | 93.2 (87.6 to 96.4) | 8.5 (4.1 to 17.8) | 0.45 (0.27 to 0.77) | 18.8 (6.0 to 58.4) |