Skip to main content

Table 2 The 14 cytokines that differed between mild or moderately severe acute pancreatitis patients and severe acute pancreatitis patients a

From: Circulating cytokines in predicting development of severe acute pancreatitis

 

All patients (N= 163)

Admission MMS <2 (n= 142)

Cytokines

Mild or moderately severe AP (n= 138)

P- valueb

Severe (n= 25)

Mild or moderately severe AP (n= 128)

P- valueb

Severe AP (n= 14)

G-CSF

119.7 (66.6-198.2)

<0.001

260.2 (132.5 to 1011.8)

118.41 (66.6 to 174.3)

0.0007

234.0 (151.2 to 531.1)

GRO-α

58.8 (35.7-92.3)

<0.001

128.2 (98.4 to 169.1)

54.5 (33.2 to 82.5)

0.002 (NS)

118.5 (62.4 to 158.4)

HGF

1055.5 (764.7-1730.6)

<0.001

3613.0 (2055.3 to 6348.8)

989.6 (753.6 to 1501.6)

<0.001

2202.6 (1554.3 to 3305.5)

IL-2Rα

214.2 (150.6-316.7)

<0.001

483.3 (385.6 to 673.3)

209.5 (145.5 to 290.4)

0.0015 (NS)

449.7 (228.1 to 504.3)

IL-6

59.7 (15.3-202.1)

<0.001

428.9 (138.5 to 1796.3)

49.9 (14.7 to 185.6)

0.0013 (NS)

234.5 (66.2 to 1931.3)

IL-8

26.6 (19.3-41.9)

<0.001

82.4 (46.4 to 115.6)

25.41 (18.0 to 37.6)

<0.001

59.7 (32.0 to 102.8)

IL-18

139.6 (91.6-187.1)

<0.001

202.8 (151.8 to 305.4)

131.5 (90.7 to 181.5)

0.062 (NS)

162.4 (135.3 to 201.6)

LIFc

0 (0)

<0.001

1 (0 to 1)

0 (0)

0.002 (NS)

1 (0 to 1)

M-CSF

14.5 (8.1-28.1)

<0.001

40.2 (18.6 to 68.6)

12.4 (5.5 to 21.5)

0.007 (NS)

28.7 (12.2 to 52.0)

MCP-1

49.0 (21.0-111.2)

<0.001

125.0 (64.6 to 199.6)

47.6 (30.0 to 100.6)

0.032 (NS)

92.1 (36.3 to 185.2)

MCP-3

17.4 (0.57-53.6)

<0.001

54.58 (24.3 to 98.7)

16.3 (0.2 to 47.9)

0.006 (NS)

52.0 (16.5 to 102.1)

β-NGF

5.79 (3.65-9.1)

<0.001

11.3 (7.4 to 15.9)

5.5 (3.4 to 8.5)

0.007 (NS)

10.4 (4.5 to 15.5)

SCF

114.1 (85.2-147.0)

0.0008

155.8 (109.2 to 256.0)

111.6 (82.0 to 143.3)

0.012 (NS)

148.5 (107.3 to 218.9)

SDF-1α

87.6 (53.5-151.5)

<0.001

163.6 (104.4 to 226.3)

86.8 (52.8 to 148.5)

0.010 (NS)

171.3 (85.1 to 234.8)

  1. aβ-NGF, β-nerve growth factor; G-CSF, granulocyte colony-stimulating factor; GRO-α, Growth-related oncogene α; HGF, Hepatocyte growth factor; IL, Interleukin; IL-1Ra, Interleukin 1 receptor antagonist; IL-2Rα, Interleukin 2 receptor α; SDF, stromal derived factor; LIF, Leukemia inhibitory factor; MCP, Monocyte chemotactic protein; M-CSF, Macrophage colony-stimulating factor; SDF, Stromal derived factor; SCF, Stem cell factor; SDF, Stromal cell–derived factor IQR, interquartile range; NS, not significant. bLevel of significance is defined as P < 0.001 (Bonferroni-adjusted). c0 = Undetectable value, 1 = Detectable value. Cytokine levels (pg/ml) are expressed as median (IQR).