Parameter | All patients (n = 42) | Intermittent dosing (n = 18) | Continuous infusion (n = 24) | P * |
---|---|---|---|---|
Vancomycin dose (mg/kg) | 27 [18 - 32] | 27 [22 - 30] | 27 [17 - 33] | 0.611 |
Elimination rate constant (h -1 )** | 0.09 [0.03 - 0.13] | 0.09 [0.03 - 0.13] | - | - |
Clearance (L/h) | 3.6 [1.9 - 5.9] | 5.1 [2.4 - 7.1] | 2.7 [1.7 - 4.1] | 0.038 |
Half-life (h) ** | 8.2 [5.4 - 24.1] | 8.2 [5.4 - 24.1] | - | - |
C min (mg/L) | 17 [8 - 23] | 10 [7- 17] | 21 [14 - 26] | 0.029 |
C min ≥15 mg/L, n (percentage) | 24 (57.1) | 7 (38.9) | 17 (70.8) | 0.038 |
AUC 0–24 /MIC | 655 [368 - 911] | 409 [246 - 712] | 830 [529 - 952] | 0.029 |
AUC 0–24 /MIC > 400, n (percentage) | 30 (71.4) | 9 (50.0) | 21 (87.5) | 0.008 |
Length of vancomycin therapy on sampling date | Â | Â | Â | Â |
 Days, n | 4 [1 - 7] | 2 [1 - 6] | 4 [1 - 7] | 0.314 |
 >2 days, n (percentage) | 23/41 (56.1) | 8/18 (44.4) | 15/23 (65.2) | 0.183 |
 >3 days, n (percentage) | 22/41 (53.7) | 8/18 (44.4) | 14/23 (60.9) | 0.295 |