New insights into the mechanisms involved in B-type natriuretic peptide elevation and its prognostic value in septic patients

Table 4 Cox multivariate survival models examining the effect of univariate determinants and independent predictors of 28-day mortality in critical sepsis patients ( N = 42)^a

	Hazard ratio	95% CI	Wald statistic	P- value
Univariate clinical determinants of 28-day mortality
APACHE II score	1.12	0.98 to 1.29	2.75	0.097
Maximum SOFA score	1.13	0.87 to 1.47	0.82	0.366
Peak noradrenaline dose on day 1	1.09	1.01 to 1.17	4.59	0.032
RVEF	0.89	0.8 to 0.99	4.79	0.029
BNP on day 1	0.988	0.996 to 1.000	4.91	0.027
Independent clinical predictors of 28-day mortality
RVEF	0.873	0.78 to 0.97	6.18	0.013
Peak noradrenaline dose on day 1	1.085	1.01 to 1.17	5.11	0.024
BNP on day 1	0.999	0.997 to 1.000	3.16	0.076

^aAPACHE II, Acute Physiology and Chronic Health Evaluation II; BNP, B-type natriuretic peptide; CI, Confidence interval; RVEF, Right ventricular ejection fraction; SOFA score, Total maximum Sequential Organ Failure Assessment score. Among all univariate determinants, RVEF, BNP and peak noradrenaline dose on day 1 independently predicted 28-day mortality. RVEF was the strongest independent predictor among them.

ISSN: 1364-8535