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Table 2 Hemodynamic changes before and after fluid challenge

From: Early fluid loading in acute respiratory distress syndrome with septic shock deteriorates lung aeration without impairing arterial oxygenation: a lung ultrasound observational study

Hemodynamic variable

T0

T1

T2

p value

HR, beats.min−1

96 (72,5 to 105.5)

93 (71.5 to 103.5)

91.5 (72.5 to 102.5)

0.067

PAM, mmHg

76.5 (71 to 83,6)

85 (76 to 90.5)a,b

81 (72.5 to 92)

<0.001*

PAPm, mmHg

25 (21 to 27)

28 (26 to 30)a,b

26 (24 to 29)c

<0.001*

PCWP, mmHg

12 (9.5 to 14)

14 (12 to 17)a,b

14 (10 to 14.2)

<0.001*

CVP, mmHg

10 (7.7 to 11.2)

12 (9.7 to 13)a,b

10 (8 to 11)

<0.001*

CI, l.min−2.m−2

3.4 ± 0.9

3.9 ± 0.9a,b

3.5 ± 1.0

<0.001*

SVRI, dyn.sec.cm−5 m2

1,576 (1,390 to 1,966)

1,427 (1,229 to 1,867)a

1,555 (1,290 to 2,229)

0.013*

PVRI, dyn.sec.cm−5 m2

311 (241 to 375)

262 (225 to 319)a

302 (265 to 403)c

<0.001*

SvO2,%

71 (67.8 to 78.6)

73.1 (68.1 to 78.8)

71.9 (68.1 to 78.4)

0.356

D (A-v)O2, mL/dL

3.5 (3.0 to 4.0)

3.3 (2.7 to 3.8)a

3.3 (2.9 to 3.9)

0.043*

DO2, mL.m−1.m−2

450 ± 127

489 ± 125a,b

456 ± 137

<0.001*

VO2, mL.m−1.m−2

118 ± 28

126 ± 29a

116 ± 31

0.03*

Lactate, mmol.L

1.9 (1.2 to 2.4)

1.55 (1.05 to 2.45)a,b

1.95 (1.15 to 2.27)

0.002*

Hb, g/dL

10 (8.8 to 10,9)

8.9 (8.1 to 10.5)a

9.6 (8.6 to 10.9)c

<0.001*

VTIAo, cm

18.3 ± 3.62

21.21 ± 4.49a,b

20.4 ± 4.63

<0.001*

E/A

1.05 ± 0.27

1.1 ± 0.31

1.11 ± 0.3

0.232

E/e’

5.17 (4.36 to 6.42)

6.27 (4.24 to 6.7)

5.65 (4.82 to 7.35)

0.657

Qva/Qt

25.3 (22.5 to 33)

26 (22.2 to 32.6)

27.5 (22.5 to 32.6)

0.307

  1. Data are presented as mean ± SD or median and interquartile interval (25 to 75%). T0, baseline; T1, immediately after fluid challenge; T2, 40 minutes after fluid challenge; HR, heart rate; PAM, mean arterial pressure; PAPm, mean pulmonary artery pressure; PCWP, pulmonary capillary wedge pressure; RAP, right atrial pressure; CI, cardiac index; SvO2, mixed venous saturation; SVRI, systemic vascular resistance index; PVRI, pulmonary vascular resistance index; D(a-v)O2, arteriovenous oxygen difference; DO2, oxygen delivery; VO2, oxygen consumption; Hb, hemoglobin; VTIAo, aortic velocity time-integral; E/A, ratio of early (E) to and late (atrial - a) ventricular filling velocity; E/e’, ratio of early transmitral flow velocity to early diastolic mitral annulus velocity; Qva/Qt, pulmonary shunt. aP <0.05 = T0 versus T1; bP <0.05 = T1 versus T2; cP <0.05 = T0 versus T2. *Statistically significant difference between the three time points.