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Table 2 Univariate analysis of factors associated with clinical cure in 63 patients with VAP

From: High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria

Variable

Clinical cure (n = 29)

Clinical failure (n = 34)

P-value

Odds ratio

95% CI

Age, years, mean ± standard deviation

58.5 ± 16.9

66.1 ± 11.8

0.04

-

-

Male, n (%)

23 (79.3)

18 (52.9)

0.02

3.4

0.98, 12.67

SAPS II score, mean ± standard deviation

48.2 ± 13.7

51.2 ± 15.4

0.42

-

-

SOFA score at infection occurrence, mean ± standard deviation

6.4 ± 2.4

8.6 ± 3.0

0.003

-

-

Causes of ICU admission, n (%)

Medical

19 (65.5)

29 (85.2)

0.06

0.32

0.07, 1.27

Non-medical

10 (34.4)a

5 (14.7)b

-

-

Comorbidities

CHF, n (%)

13 (44.8)

14 (41.1)

0.77

1.16

0.37, 3.54

COPD, n (%)

6 (20.6)

4 (11.7)

0.33

1.95

0.4, 10.47

CRF, n (%)

4 (13.7)

5 (14.7)

0.91

0.92

0.16, 4.85

Malignancies, n (%)

4 (13.7)

6 (17.6)

0.74

0.75

0.14, 3.59

Diabetes, n (%)

6 (20.6)

7 (20.5)

0.99

1

0.24, 4.07

Immunosuppressive status, n (%)

4 (13.7)

5 (14.7)

0.91

0.92

0.16, 4.84

Comorbidities >1, n (%)

17 (58.6)

21 (61.7)

0.79

0.87

0.28, 2.72

Initial inadequate treatment, n (%)

11 (37.9)

22 (64.7)

0.03

0.33

0.1, 1.04

Duration of TGC treatment, days, median (IQR)

11 (6 to 13)

7 (3 to 10)

0.03

-

-

Septic shock at infection occurrence, n (%)

11 (37.9)

17 (50)

0.33

0.61

0.2, 1.87

Standard-dose group, n (%)

10 (34.4)

20 (58.8)

0.05

-

-

High-dose group, n (%)

19 (65.5)

14 (41.1)

2.71

0.86, 8.64

Concomitant use of other active antibiotics, n (%)

26 (89.7)

27 (79.4)

0.27

2.24

0.44, 14.72

ICU LoS, days, median (IQR)

35 (16 to 61)

26 (14 to 33)

0.06

-

-

ICU LoS before infection occurrence, days, median (IQR)

17 (6 to 27)

10.5 (4 to 21)

0.14

-

-

Duration of MV, days, median (IQR)

21 (13 to 43)

23 (11 to 33)

0.83

-

-

Duration of MV before infection occurrence, days, median (IQR)

17 (5 to 22)

11 (5 to 18)

0.21

-

-

Responsible pathogens, n (%)

Acinetobacter baumannii XDR

13 (44.8)

15 (44.1)

0.95

1.02

0.33, 3.13

Klebsiella pneumoniae MDR/XDR

16 (55.1)

14 (41.1)

0.26

1.75

0.58, 5.38

  1. Non-medical causes included: asix surgical and five trauma; btwo surgical and three trauma. Data are shown as median with 25th and 75th percentile, until otherwise indicated. VAP, ventilator-associated pneumonia; SAPS II, simplified acute physiology score II; SOFA, sequential organ failure assessment; CHF, chronic heart failure; COPD, chronic obstructive pulmonary disease; CRF, chronic renal failure; TGC, tigecycline; LoS, length of stay; MV, mechanical ventilation; MDR, multidrug resistant; XDR, extensively drug-resistant. ‘-’ stands for Not Applicable.
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Critical Care

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