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Table 2 Data from single permeabilized diaphragm fibers

From: Hyperglycemia-induced diaphragm weakness is mediated by oxidative stress

Experimental group

Maximum force (kPa)

N value

pCa50

Control

182.9 ± 1.8

5.98 ± 0.19

5.81 ± 0.01

Hyperglycemia

85.7 ± 2.0*

5.17 ± 0.27*

5.69 ± 0.07

Hyperglycemia + PEG-SOD

148.6 ± 2.4*

5.76 ± 0.22

5.78 ± 0.01

Hyperglycemia + Denatured PEG-SOD

90.9 ± 1.5*

4.33 ± 0.18*

5.72 ± 0.01

  1. Single fiber maximum force is reported as absolute force generation per fiber cross sectional area in kPa. N is the Hill coefficient and indicates thin filament cooperativity. pCa50 is the calcium concentration at which half maximal activation occurs. Data are presented as the mean ± standard error of the mean (SEM) and include all fiber types for each experimental group (n = 90/group). *Significantly different when compared to control group (P < 0.001).