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Table 2 Logistic regressions of 30-day all-cause mortality, using covariates of age, acute physiology score, and Charlson score

From: Coefficient of glucose variation is independently associated with mortality in critically ill patients receiving intravenous insulin

 

Odds ratio (95% CI) (model 1)

P-value (model 1)

Odds ratio (95% CI) (model 2)

P-value (model 2)

All patients (n = 6,101)

    

Age (decade)

1.16 (1.10, 1.22)

<0.001

1.15 (1.09, 1.22)

<0.001

Charlson score

1.21 (1.14, 1.28)

<0.001

1.20 (1.13, 1.27)

<0.001

Acute physiology score

1.09 (1.07, 1.10)

<0.001

1.08 (1.07, 1.10)

<0.001

Hypoglycemia

1.53 (1.33, 1.77)

<0.001

1.34 (1.16, 1.56)

<0.001

Diabetes

0.63 (0.54, 0.74)

<0.001

0.55 (0.46, 0.64)

<0.001

Interaction of age and diabetes

1.09 (0.99, 1.20)

0.070

1.11 (1.01, 1.22)

0.033

Interaction of Charlson and acute physiology scores

1.00 (0.99, 1.00)

0.005

1.00 (0.99, 1.00)

0.016

Coefficient of variation (10%)

  

1.23 (1.16, 1.31)

<0.001

Diabetic patients (n = 2,847)

    

Age (decade)

1.29 (1.19, 1.40)

<0.001

1.30 (1.19, 1.41)

<0.001

Charlson score

1.25 (1.14, 1.37)

<0.001

1.25 (1.14, 1.36)

<0.001

Acute physiology score

1.12 (1.09, 1.16)

<0.001

1.12 (1.08, 1.16)

<0.001

Hypoglycemia

1.42 (1.15, 1.75)

<0.001

1.30 (1.05, 1.61)

0.020

Interaction of Charlson and acute physiology scores

0.99 (0.99, 1.00)

0.001

0.99 (0.99, 1.00)

0.018

Coefficient of variation (10%)

  

1.15 (1.06, 1.24)

0.001

Non-diabetic patients (n = 3,254)

    

Age (decade)

1.14 (1.08, 1.21)

<0.001

1.13 (1.07, 1.20)

<0.001

Charlson score

1.31 (1.20, 1.43)

<0.001

1.30 (1.18, 1.42)

<0.001

Acute physiology score

1.09 (1.07, 1.11)

<0.001

1.08 (1.06, 1.10)

<0.001

Hypoglycemia

1.65 (1.36, 2.01)

<0.001

1.35 (1.10, 1.66)

0.004

Interaction of Charlson and acute physiology scores

0.99 (0.99, 1.00)

0.001

0.99 (0.99, 1.00)

0.003

Coefficient of variation (10%)

  

1.37 (1.25, 1.50)

<0.001

  1. Model 2 includes coefficient of variation. Age is mean-centered. Both age and coefficient of variation were scaled for clinical relevance. Acute physiology score is calculated from the acute physiology and chronic health evaluation II (APACHE II), omitting age and chronic health parameters. Hypoglycemia is defined as having at least one measured blood glucose <60 mg/dL while supported with eProtocol-insulin. Interactions were included to account for multi-co-linearity. Initial model also included gender and choice of blood glucose target, both of which were omitted from the final model due to non significance. The likelihood ratio test demonstrates an independent effect of coefficient of variation on mortality in the diabetic (χ2 = 11.20, P = 0.001), non-diabetic (χ2 = 44.40, P <0.001), and combined groups (χ2 = 45.62 P <0.001).