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Table 3 Baseline characteristics and suspected VAP episode description of the study patients according to the 30-day mortality

From: Impact of prior statin therapy on the outcome of patients with suspected ventilator-associated pneumonia: an observational study

 

Survivors

Nonsurvivors

P

(n = 249)

(n = 100)

Age (years)

62.0 (17.0-94.0)

68.5 (32.0-90.0)

<0.01

SAPS II (points)

47.0 (6.0-109.0)

55.0 (15.0-99.0)

<0.01

Gender, male (n (%))

182 (73.1)

72 (72.0)

0.83

Underlying disease(s) (n (%))

   

 Chronic renal failure

12 (4.8)

11 (11.0)

0.04

 Cardiac chronic disease

84 (33.9)

54 (54.0)

<0.01

 Diabetes mellitus

45 (18.1)

22 (22.0)

0.41

 COPD

45 (18.1)

21 (21.0)

0.53

 Cirrhosis

6 (2.4)

11 (11.0)

<0.01

 Immunosuppression

9 (3.6)

8 (8.0)

0.09

 Cancer

25 (10.1)

6 (6.0)

0.21

Nursing-home resident (n (%))

16 (6.4)

0 (0.0)

<0.01

Main admission diagnosis

  

0.02

 Respiratory distress (n (%))

101 (40.6)

32 (32.0)

0.13

 Extrapulmonary sepsis (n (%))

64 (25.7)

43 (43.0)

<0.01

 Neurologic failure (n (%))

40 (16.1)

10 (10.0)

0.14

 Abdominal surgery (n (%))

14 (5.6)

3 (3.0)

0.30

 Miscellaneous (n (%))

30 (12.0)

12 (12.0)

0.99

CPIS day 1

6.0 (2.0-11.0)

5.0 (3.0-9.0)

0.06

CPIS day 3

7.0 (5.0-13.0)

7.0 (5.0-11.0)

0.20

SOFA day 1

7.0 (4.0-17.0)

10.0 (4.0-16.0)

<0.01

SOFA day 3

7.0 (4.0-16.0)

9.0 (4.0-18.0)

<0.01

Length of ICU stay until VAP (days)

10.0 (2.0-157.0)

11.0 (2.0-72.0)

0.48

Duration of MV until VAP (days)

10.0 (2.0-156.0)

10.0 (2.0-70.0)

0.37

Septic shock (VAP day 1) (n (%))

71 (28.6)

46 (46.0)

<0.01

Late-onset VAP (≥5 days after MV onset) (n (%))

166 (66.7)

75 (75.0)

0.13

MDR bacteria (n (%))

76 (30.8)

41 (41.0)

0.05

Appropriate antibiotic therapy within the first 24 hours of VAP (n (%))

193 (78.4)

69 (69.0)

0.16

Steroids during VAP period (n (%))

89 (36.8)

64 (64.0)

<0.01

Statin exposure prior to ICU admission (n (%))

60 (24.1)

33 (33.0)

0.09

Statin continuation after ICU admission (n (%))

37 (14.8)

15 (15.0)

0.97

  1. VAP, ventilator-associated pneumonia; SAPS II, simplified acute physiology score II; COPD, chronic obstructive pulmonary disease; CPIS, clinical pulmonary infection score; SOFA, sequential organ failure assessment; ICU, intensive care unit; MV, mechanical ventilation; MDR, multidrug resistant.
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