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Table 4 Factors associated with guideline concordance: multilevel logistic regression

From: Thromboprophylaxis patterns and determinants in critically ill patients: a multicenter audit

Three-level model

Odds ratio (95% CI)

P value

Patient factors

  

 Surgical admission

1.09 (0.68, 1.75)

0.718

 APACHE II score (10-point increase)

1.49 (1.17, 1.89)

0.001

 Cancera

3.22 (1.81, 5.72)

<0.001

 History of venous thromboembolism

3.94 (1.46, 10.66)

0.007

 Body mass index (10-point increase)

1.32 (1.05, 1.65)

0.018

Daily factorsb

  

 Any dialysis

0.79 (0.45, 1.40)

0.422

 Invasive mechanical ventilation

1.83 (1.32, 2.52)

<0.001

 Vasopressors or inotropes

1.26 (0.90, 1.78)

0.184

Site factors

  

 Dedicated thrombosis consulting service

1.91 (0.95, 3.86)

0.069

 Preprinted orders including thromboprophylaxis

1.00 (0.51, 1.98)

0.989

  1. Results of the multilevel logistic regression model examining determinants of guideline concordance (use of any pharmacological thromboprophylaxis unless contraindications exist). The three levels are center, patient, and ICU-day. There were 10,540 patient-days (10,154 with concordance, 386 without), n = 1,533 patients. Body mass index values were missing for 402 of the 1,935 patients enrolled in the study. These patients were therefore excluded from the regression analysis. APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval. aCancer refers to lymphoma, metastatic cancer, leukemia, multiple myeloma, active solid malignancy, or history of solid malignancy. bDaily factors reflect exposure in the preceding 3 days.