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Table 2 Multivariable analysis of early (seven-day) mortality

From: Guideline-concordant administration of prothrombin complex concentrate and vitamin K is associated with decreased mortality in patients with severe bleeding under vitamin K antagonist treatment (EPAHK study)

Variable All patients (N = 822) ICH (N = 262)
N OR (95% CI) P N OR (95% CI) P
Type of hemorrhage 822      
  “Other”* 189 1.0
  Gastrointestinal 264 0.61 (0.22 to 1.70) NS
  Deep-muscle 107 0.51 (0.14 to 1.93) NS
  ICH 262 5.05 (1.97 to 12.94) <0.001
Age (years) 822    262   
  ≤65 years 129 1.0   34 1.0
  66 to 75 144 1.01 (0.35 to 2.93) NS 47 2.32 (0.57 to 9.47) NS
  76 to 85 368 1.67 (0.68 to 4.10) NS 122 2.71 (0.78 to 9.34) NS
  >85 181 2.21 (0.84 to 5.77) NS 59 3.79 (1.01 to 14.26) 0.049
Admission INR 822    262   
  ≤1.5 45 1.0   17 1.0  
  No INR 38 0.76 (0.12 to 4.71) NS 13 1.01 (0.11 to 9.71) NS
  >1.5 to 4 394 1.12 (0.33 to 3.80) NS 162 1.40 (0.32 to 6.19) NS
  >4 345 1.36 (0.38 to 4.87) NS 70 1.56 (0.31 to 7.81) NS
GCS score 813    261   
  >13 684 1.0   149 1.0
  9 to 13 65 3.67 (1.80 to 7.51) <0.001 51 4.23 (1.87 to 9.53) <.001
  ≤8 64 30.35 (13.43 to 68.61) <0.001 61 39.81 (15.70 to 100.91) <.001
SAP 819    262   
  90 to 140 mmHg 411 1.0   64 1.0  
  <90 mmHg 74 7.91 (3.06 to 20.44) <0.001 3 0.67 (0.01 to 33.01) NS
  >140 mmHg 334 1.15 (0.58 to 2.28) NS 195 1.29 (0.55 to 3.06) NS
VKA reversal 822    262   
Guideline concordant 313 1.0 0.011 116 1.0 .002
Not guideline-concordant 509 2.15 (1.20 to 3.88)   146 3.23 (1.53 to 6.79)  
   Hosmer–Lemeshow Goodness-of-Fit Test: Pr >χ2 = 0.99   Hosmer–Lemeshow Goodness-of-Fit Test: Pr >χ2 = 0.52
c-statistic = 0.89 c-statistic = 0.86
  1. CI, confidence interval; ICH, intracranial hemorrhage; GCS, Glasgow coma scale; NS, not statistically significant; OR, odds ratio; SAP, systolic arterial blood pressure; trt: treatment.
  2. *“Other” types include hemopericardium (N = 1), hemothorax (N = 15), vascular bound (N = 4), emergency procedures (N = 126) and shock or red blood cell transfusion for epistaxis (N = 55), hematuria (N = 34) or a wound of the scalp (N = 4).