Table 3 Subgroup analyses
From: Parenteral glutamine supplementation in critical illness: a systematic review
| Â | Overall mortality | Â | Â | Hospital mortality | Â | Â | Infectious complications | Â | ICU LOS | Â | Â | VAP | Â | Â | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subgroup analysis | Number of trials | Number of patients | Effect on overall mortality [RR (95% CI), p] | Test for subgroup differences | Number of trials | Number of patients | Effect on hospital mortality [RR (95% CI), p] | Test for subgroup differences | Number of trials | Number of patients | Effect on infectious complications [RR (95% CI), P] | Test for subgroup differences | Number of trials | Number of patients | Effect on ICU LOS [WMD (95% CI), P] | Test for subgroup differences | Number of trials | Number of patients | Effect on VAP [RR (95% CI), P] | Test for subgroup differences |
Study Quality | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Low quality (<8) | 5 | 214 | 0.81 (0.44, 1.48), P = 0.49 | P = 0.79 | 3 | 134 | 0.26 (0.06, 1.19), P = 0.08 | P = 0.21 | NA | NA | NA | |||||||||
High quality (≥8) | 19 | 2103 | 0.88 (0.74, 1.04) P = 0.12 |  | 10 | 733 | 0.70 (0.52, 0.94), P = 0.02 |  | ||||||||||||
Number of sites | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Single center | 19 | 1011 | 0.75 (0.60, 0.93), P = 0.009 | P = 0.04 | 11 | 603 | 0.64 (0.47, 0.88), P = 0.006 | P = 0.45 | 8 | 371 | 0.77 (0.60, 0.98), P = 0.03 | P = 0.16 | NA | 4 | 226 | 0.86 (0.58, 1.28), P = 0.45 | P = 0.34 | |||
Multi-center | 5 | 1306 | 1.03 (0.83,1.28) P = 0.79 |  | 2 | 264 | 0.86 (0.43, 1.71), P = 0.67 |  | 4 | 893 | 0.97 (0.77, 1.23) P = 0.83 |  | 2 | 264 | 0.63 (0.38, 1.04) P = 0.07 |  | ||||
PN vs. EN | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Patients on PN | 20 | 2128 | 0.84 (0.71, 1.01) P = 0.07 | P = 0.66 | NA | 10 | 1140 | 0.89 (0.74, 1.06) P = 0.20 | P = 0.27 | 8 | 354 | -2.30 (-6.50, 1.90) P = 0.28 | P = 0.42 | 4 | 366 | 0.79 (0.57, 1.09) P = 0.16 | P = 0.40 | |||
Patients on EN | 4 | 184 | 0.94 (0.61, 1.47), P = 0.79 |  | 2 | 124 | 0.68 (0.45, 1.05), P = 0.08 |  | 3 | 184 | -0.47 (-1.84, 0.90) P = 0.50 |  | 2 | 124 | 0.44 (0.11, 1.67), P = 0.23 |  | ||||