Figure 3
From: A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury
Incidence of pneumonia during the course of treatment. (a) In total 12 trials involving 689 patients reported pneumonia in patients during the course of treatment. When the data from 12 randomised controlled trials (RCTs) were aggregated, therapeutic hypothermia had no effect on increasing onset of new pneumonia (relative risk (RR) = 0.81, 95% CI = 0.62, 1.05, P = 0.12). (b) Trials assessed as lower risk of bias: 9 trials, involving 504 patients, assessed as having lower risk of bias (domain-based assessment) were included in this analysis. When the data from the 9 RCTs that reported pneumonia were aggregated, therapeutic hypothermia had no effect on increasing onset of new pneumonia (RR = 0.87, 95% CI = 0.71, 1.07, P = 0.17).