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Figure 2 | Critical Care

Figure 2

From: A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury

Figure 2

Poor outcome at final follow-up. (a) In total 20 trials involving 1,885 patients reported death, vegetative state, and long-term disability. When the results of 20 randomised controlled trials (RCTs) that evaluated poor outcome were statistically aggregated, therapeutic hypothermia was associated with a significant reduction in poor outcome (relative risk (RR) = 1.49, 95% CI = 1.27, 1.74, P <0.00001). (b) Trials assessed as lower risk of bias: 16 trials, involving 964 patients, and assessed as lower risk of bias (domain-based assessment) were included in this analysis. When the results of 16 RCTs that evaluated poor outcome were statistically aggregated, therapeutic hypothermia was associated with a significant reduction in poor outcome (RR = 1.67, 95% CI = 1.45, 1.92, P <0.00001).

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