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Figure 5 | Critical Care

Figure 5

From: Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin

Figure 5

Mechanical ventilation induced systemic hyperinflammation in pneumonia. Pneumococcal pneumonia (S.p.) was induced 24 hours before mechanical ventilation (MV) was performed for 6 hours. Continuous adrenomedullin (AM) infusion (0.05 mg/kg/hour) started with the onset of MV. Nonventilated mice were sacrificed 30 hours after infection. (A) Cytokine levels of IL-6, keratinocyte-derived cytokine (KC) and IL-10 were measured in blood plasma **P < 0.01; n = 5 or 6 each). (B) Whole blood leukocytes were quantified and differentiated by flow cytometry (*P < 0.05, **P < 0.01; n = 5 each). PMN, polymorphonuclear neutrophils.

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