Mechanical ventilation induced systemic hyperinflammation in pneumonia. Pneumococcal pneumonia (S.p.) was induced 24 hours before mechanical ventilation (MV) was performed for 6 hours. Continuous adrenomedullin (AM) infusion (0.05 mg/kg/hour) started with the onset of MV. Nonventilated mice were sacrificed 30 hours after infection. (A) Cytokine levels of IL-6, keratinocyte-derived cytokine (KC) and IL-10 were measured in blood plasma **P < 0.01; n = 5 or 6 each). (B) Whole blood leukocytes were quantified and differentiated by flow cytometry (*P < 0.05, **P < 0.01; n = 5 each). PMN, polymorphonuclear neutrophils.