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Table 3 Subgroup analysis by timing of starting corticosteroid therapy

From: Exploring the heterogeneity of effects of corticosteroids on acute respiratory distress syndrome: a systematic review and meta-analysis

Timing of starting steroids Number of studies Number of patients Relative risk (95% CI) I2
Preventive therapy     
 Randomized controlled trials 3 154 1.24 (0.57 to 2.72) 80%
Early ARDS (≤3 days)     
 Randomized controlled trials 3 367 0.86 (0.71 to 1.04) 17%
 Cohort studies 4 303 1.00 (0.24 to 4.20) 70%
Persistent ARDS (≥5 days)     
 Randomized controlled trials 2 204 0.52 (0.11 to 2.52) 79%
 Cohort studies 3 105 0.73 (0.44 to 1.23) 0%
  1. Three studies were excluded in this analysis due to no report of treatment timing.