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Table 2 Effects of corticosteroids on mortality in different etiologies of ARDS

From: Exploring the heterogeneity of effects of corticosteroids on acute respiratory distress syndrome: a systematic review and meta-analysis

Etiology of ARDSa Number of studies Number of patients Relative risk (95% CI) I2
Unselected ARDS     
 Randomized controlled trials 3 370 0.88 (0.65 to 1.18) 28%
 Cohort studies 4 238 1.12 (0.78 to 1.60) 40%
Influenza-related ARDS b     
 Cohort studies 3 283 2.45 (1.40 to 4.27) ** 0%
Sepsis-related ARDS     
 Randomized controlled trials 2 201 0.50 (0.12 to 2.02) 76%
 Cohort studies 2 208 1.04 (0.58 to 1.85) 0%
Post-operative ARDS b     
 Cohort studies 1 20 0.10 (0.01 to 0.63) * -
  1. aExcludes the studies of preventive use of corticosteroids; bno randomized controlled trials available. *P-value <0.05. ** P-value <0.005. ARDS, acute respiratory distress syndrome.