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Table 2 Histological lung injury score

From: Open lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage

 

NBD

BD

 

LVT/OLPEEP

HVT/LPEEP

LVT/OLPEEP

HVT/LPEEP

Total

2.5 (1.75/3)†

4.5 (3.75/6.25)‡

3 (3/3.25)*

8 (6.5/8.75)

Haemorrhage

0 (0/0)

0 (0/0)

0 (0/0)

0 (0/0.75)

Inflammation

0 (0/0)†

2 (0.75/2.5)

0 (0/0.25)*

2.5 (2/3)

Oedema

0 (0/0)†#

1 (0/1)

1 (0/1)

1.5 (1/2)

Atelectasis

1 (0.75/1)

0 (0/1)

1 (1/1)

0 (0/0.75)

Over-inflation

1 (1/1.25)

2 (1/2.25)

1 (1/1.25)*

2.5 (2/3)

  1. All values presented as median and 25% to 75% interquartile ranges.
  2. BD; brain damage; NBD, no brain damage; HVT/LPEEP, six hours of high tidal volume ventilation with low PEEP; LVT/OLPEEP, six hours of low tidal volume ventilation with open lung positive end-expiratory pressure;
  3. †: P <0.05 NBD LVT/OLPEEP vs. NBD HVT/LPEEP.
  4. *: P <0.05 BD LVT/OLPEEP vs. BD HVT/LPEEP.
  5. #: P <0.05 NBD LVT/OLPEEP vs. BD LVT/OLPEEP.
  6. ‡: P <0.05 NBD HVT/LPEEP vs. BD HVT/LPEEP.
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