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Table 1 Physiological data at baseline and at the end of the experiment

From: Open lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage

 

BASELINE

END

END

 

LVT/OLPEEP n = 14

HVT/OLPEEP n = 14

NBD

BD

LVT/OLPEEP n = 7

HVT/LPEEP n = 6

LVT/OLPEEP n = 7

HVT/LPEEP n = 4

VT (ml/kg)

6.1 ± 0.3 +

11.9 ± 0.2

5.9 ± 0.2 *

12.2 ± 0.3

6.0 ± 0.3 #

11.9 ± 0.2

PEEP (cmH2O)

5.0 ± 1.0 +

2.0 ± 0.1

4.75 ± 1.0 *

1.99 ± 0.0

5.2 ± 1.1 #

2.0 ± 0.0

Pinsp (cmH2O)

12.6 ± 1.5 +

16.5 ± 2.4

15.0 ± 2.2 *

18.8 ± 4.8

15.0 ± 0.9 #

23 ± 7.6

Pmean (cmH2O)

7.9 ± 1.1 +

6.0 ± 1.1

8.3 ± 1.1

8.7 ± 2.0

9.0 ± 0.9

10.3 ± 2.7

RR (bpm)

100.3 ± 2.9 +

31.4 ± 2.4

108.1 ± 5.3 *‡

30.6 ± 4.2

102.3 ± 4.4 #

29.2 ± 3.8

Estat, RS (cmH2O.ml−1)

2.41 ± 0.4

2.39 ± 0.4

3.42 ± 0.9

2.74 ± 0.9

3.06 ± 0.4

3.44 ± 1.2

Estat, L (cmH2O.ml−1)

1.83 ± 0.4

1.9 ± 0.4

2.59 ± 1.0

2.23 ± 0.9

2.29 ± 0.4

2.90 ± 1.2

Estat, CW (cmH2O.ml−1)

0.58 ± 0.2

0.37 ± 0.2

0.49 ± 0.3

0.31 ± 0.1

0.76 ± 0.3

0.50 ± 0.2

PaO2/FiO2

439.2 ± 47.4

463.8 ± 32.5

458.8 ± 44.9

410.2 ± 129.9

470.5 ± 26.7 #

321.6 ± 120.0

PaCO2 (mmHg)

47.5 ± 9.7

41.2 ± 8.6

47.6 ± 12.1

37.5 ± 5.6

39.0 ± 4.5

37.35 ± 5.6

pHa

7.34 ± 0.0

7.34 ± 0.0

7.34 ± 0.1 ‡

7.38 ± 0.0

7.42 ± 0.0

7.41 ± 0.1

HR (bpm)

255.4 ± 40.6

284.0 ± 42.7

230.5 ± 60.0 ‡

262.5 ± 31.1

292.5 ± 52.6

314.0 ± 90.9

MAP (mmHg)

63.2 ± 11.4

70.5 ± 8.8

75.9 ± 10.6 ‡

72.4 + 20.3 $

64.6 ± 8.7

51.6 ± 14.1

  1. BD, brain damage; Estat,CW, chest wall static elastance; Estat,L, lung static elastance; Estat,RS, respiratory system static elastance; HR, heart rate; HVT/LPEEP, six hours of high tidal volume ventilation with low PEEP, no brain damage; LVT/OLPEEP, six hours of low tidal volume ventilation with open lung positive end-expiratory pressure; MAP, mean arterial pressure; NBD, no brain damage; PaCO2, partial pressure of carbon dioxide; PaO2/FiO2, ratio of partial pressure arterial oxygen and fraction of inspired oxygen; PEEP, positive end-expiratory pressure; pHa, arterial pH; Pinsp, end-inspiratory pressure; RR, respiratory rate; VT, tidal volume.
  2. Values are mean ± standard deviation.
  3. +: P <0.05 LVT/OLPEEP BL vs. HVT/LPEEP BL.
  4. *: P <0.05 NBD LVT/OLPEEP End vs. NBD HVT/LPEEP End.
  5. #: P <0.05 BD LVT/OLPEEP End vs. BD HVT/LPEEP End.
  6. ‡: P <0.05 NBD LVT/OLPEEP End vs. BD LVT/OLPEEP End.
  7. $: P <0.05 NBD HVT/LPEEP End vs. BD HVT/LPEEP End.