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Table 5 Univariate Cox proportional hazards models for 28-day and 6-month mortality for patients admitted to the ICU with CAP

From: Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort

 

Increment

28-day mortality

6-month mortality

  

Hazard ratio

95% CI

P-value

Hazard ratio

95% CI

P-value

APACHE II score

 

1.1

1.08, 1.12

<1E-14

1.08

1.07-1.1

0.00E + 00

Staphylococcus aureus

 

1.65

0.99, 2.75

5.59E-02

2.03

1.38, 2.97

3.02E-04

Haematocrit

%

0.95

0.93, 0.98

2.98E-05

0.96

0.94, 0.98

6.19E-06

pH value

0.1 unit

0.7

0.62, 0.77

2.31E-11

0.75

0.69, 0.82

1.81E-10

Septic shock

 

1.98

1.48, 2.64

3.61E-06

1.6

1.28, 2

3.92E-05

Diffuse bilateral change on CXR

 

1.27

0.94, 1.7

1.14E-01

1.54

1.22, 1.94

2.44E-04

Bilirubin

10 μmol/L

1.04

1.02, 1.07

8.64E-04

1.04

1.02, 1.07

2.86E-04

Creatinine day 1

10 μmol/L

1.02

1.01, 1.03

1.41E-03

1.02

1.01, 1.03

1.85E-04

Lowest heart rate day 1

 

1.01

1, 1.02

2.35E-03

1.01

1.01, 1.02

4.62E-04

Lowest MAP day 1

 

0.97

0.96, 0.98

4.96E-06

0.98

0.97, 0.99

1.95E-06

Lowest SBP day 1

mmHg

0.98

0.97, 0.99

7.09E-08

0.98

0.98, 0.99

5.33E-07

Need for any ventilatory support

 

3.17

1.72, 5.82

2.01E-04

3.63

2.2, 6

5.07E-07

Mechanical ventilation

 

2.17

1.46, 3.21

1.19E-04

2.21

1.62, 3.03

6.41E-07

Renal failure in week 1

 

1.99

1.5, 2.64

2.04E-06

1.65

1.32, 2.07

1.40E-05

Need for renal replacement week 1

 

2.45

1.8, 3.32

9.00E-09

2.2

1.71, 2.82

6.09E-10

SOFAday1

 

1.12

1.08, 1.17

2.14E-08

1.11

1.08, 1.15

3.22E-10

Urine volume day 1

100 mL/day

0.97

0.96, 0.99

1.09E-04

0.97

0.96, 0.98

3.90E-06

  1. All values are significant at a type I error rate of 5% after a Bonferroni correction to take account of the multiple testing of 64 variables (a P-value <0.00078 was considered to be statistically significant). Results are adjusted for age and sex. All day-1 variables unless specified otherwise. RRT, renal replacement therapy; MV, mechanical ventilation; NIV, non-invasive ventilation; SBP, systolic blood pressure; MAP, mean arterial pressure.
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